Molecular structure of Ubiquitin Isopeptidase Inhibitor I, G5, CAS Number: 108477-18-5
Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5)
See product citations (5)
Alternate Names:
3,5-bis((4-Nitrophenyl)methylene)-1,1-dioxide, tetrahydro-4H-thiopyran-4-one
Application:
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated unsaturated dienone compound
CAS Number:
108477-18-5
Purity:
≥97%
Molecular Weight:
414.4
Molecular Formula:
C19H14N2O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ubiquitin Isopeptidase Inhibitor I, G5 is a cell-permeable cross-conjugated alpha,beta-unsaturated dienone compound reported to induce caspase activation and apoptosis via the apoptosome-independent mitochondrial pathway by selectively inhibiting ubiquitin isopeptidase activity. The cellular expression of Bax and Bak is essential for Ubiquitin Isopeptidase Inhibitor I, G5-activated apoptosis, while Bcl-2 appears to protect cells against the effect of Ubiquitin Isopeptidase Inhibitor I, G5. Ubiquitin Isopeptidase Inhibitor I, G5 is reported to exhibit similar pharmacological effects as Ubiquitin Isopeptidase Inhibitor II, F6 but is reported to be more potent (sc-296678). Additionally, at higher concentrations, it may act to induce necrosis in apoptosis-resistant MEFs-DKO.
Ubiquitin Isopeptidase Inhibitor I, G5 (CAS 108477-18-5) References
- Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. | Aleo, E., et al. 2006. Cancer Res. 66: 9235-44. PMID: 16982768
- The Isopeptidase Inhibitor G5 Triggers a Caspase-independent Necrotic Death in Cells Resistant to Apoptosis: A COMPARATIVE STUDY WITH THE PROTEASOME INHIBITOR BORTEZOMIB. | Fontanini, A., et al. 2009. J Biol Chem. 284: 8369-81. PMID: 19139105
- Proteasome-dependent processing of topoisomerase I-DNA adducts into DNA double strand breaks at arrested replication forks. | Lin, CP., et al. 2009. J Biol Chem. 284: 28084-28092. PMID: 19666469
- A high-throughput image-based screen for the identification of Bax/Bak-independent caspase activators against drug-resistant cancer cells. | Seervi, M., et al. 2014. Apoptosis. 19: 269-84. PMID: 24220853
- Antagonizing c-Cbl enhances EGFR-dependent corneal epithelial homeostasis. | Rush, JS., et al. 2014. Invest Ophthalmol Vis Sci. 55: 4691-9. PMID: 24985478
- Phosphorylation-dependent degradation of MEF2C contributes to regulate G2/M transition. | Badodi, S., et al. 2015. Cell Cycle. 14: 1517-28. PMID: 25789873
- Increased stability of heterogeneous ribonucleoproteins by a deacetylase inhibitor. | Koumbadinga, GA., et al. 2015. Biochim Biophys Acta. 1849: 1095-103. PMID: 25959059
- NUP98 fusion oncoproteins interact with the APC/C(Cdc20) as a pseudosubstrate and prevent mitotic checkpoint complex binding. | Salsi, V., et al. 2016. Cell Cycle. 15: 2275-87. PMID: 27097363
- Regulation of oxidized LDL-induced inflammatory process through NLRP3 inflammasome activation by the deubiquitinating enzyme BRCC36. | Singh, M., et al. 2019. Inflamm Res. 68: 999-1010. PMID: 31485755
- The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models. | Cheng, X., et al. 2020. Biochem Biophys Res Commun. 522: 647-654. PMID: 31787240
- Knockout of c-Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation. | Crotchett, BLM. and Ceresa, BP. 2021. Pharmacol Res Perspect. 9: e00756. PMID: 33811466
- TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose. | Toyoda, Y., et al. 2021. J Cell Sci. 134: PMID: 34028542
- Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells. | Shao, X., et al. 2022. Acta Pharm Sin B. 12: 1856-1870. PMID: 35847510
Inhibitor of:
Protease, PSMC6, and Ub.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubiquitin Isopeptidase Inhibitor I, G5, 10 mg | sc-356181 | 10 mg | $257.00 |