Ubiquitin Aldehyde has shown to inhibit the activity of USP5 and UCH-L1. It is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. It inhibits deubiquitinylating enzyme activity and can be used to identify such activity to determine the inhibition kinetics for a particular enzyme. Ubiquitin Aldehyde is a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including UCHs (ubiquitin C-terminal hydrolases), USPs (ubiquitin-specific proteases) and DUBs (deubiquitinylating enzymes). Concentration recommended for maximal inhibition is 2-5μM.
See how others have used Ubiquitin Aldehyde. Click on the entry to view the PubMed entry .
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