Ubiquitin Aldehyde MW: 8500
An inhibitor of isopeptidase T and Ubiquitin C-terminal Hydrolase activity.

Ubiquitin Aldehyde

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Application: Ubiquitin Aldehyde is an inhibitor of isopeptidase T and Ubiquitin C-terminal Hydrolase activity
Purity: ≥95%
Molecular Weight: 8500
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ubiquitin Aldehyde has shown to inhibit the activity of USP5 and UCH-L1. It is useful in the stabilization of ubiquitin-protein conjugates in vitro, enhancing their accumulation in cell lysates and tissue extracts. It inhibits deubiquitinylating enzyme activity and can be used to identify such activity to determine the inhibition kinetics for a particular enzyme. Ubiquitin Aldehyde is a potent, highly specific inhibitor of all ubiquitin deconjugating enzymes, including UCHs (ubiquitin C-terminal hydrolases), USPs (ubiquitin-specific proteases) and DUBs (deubiquitinylating enzymes). Concentration recommended for maximal inhibition is 2-5μM.

Formulation :
1mg/ml in water containing 0.15M HCl
Appearance :
Aqueous solution
Physical State :
Liquid
Solubility :
Soluble in aqueous buffers, DMSO (50 mg/ml), and water.
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
EC Number :
231-791-2

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Ubiquitin AldehydeProduct Citations

See how others have used Ubiquitin Aldehyde. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 17 total

PMID: # 30532073  Liu, B. et al. 2018. Oncogene.

PMID: # 30340022  Wan, W. et al. 2018. Mol. Cell. 72: 303-315.e6.

PMID: # 28672898  Geng, Z.|Wei, L.|Zhang, C.|Yan, X.| et al. 2017. Exp Ther Med. 14: 91-96.

PMID: # 28775317  Sun, W. et al. 2017. Sci Rep. 7: 7190.

PMID: # 29084198  Hein, JB. et al. 2017. Nat. Cell Biol. 19: 1433-1440.

PMID: # 22163316  Ferrero, M. et al. 2011. PLoS ONE. 6: e28602.

PMID: # 16211010  Hu M, Li P, Song L, Jeffrey PD, Chenova TA, Wilkinson KD, Cohen RE, Shi Y. et al. 2005. EMBO J. 24: 3747-3756.

PMID: # 14559776  Burnett, B. et al. 2003. Hum. Mol. Genet. 12: 3195-3205.

PMID: # 14663138  Shackelford, J. et al. 2003. Proc. Natl. Acad. Sci. USA. 100: 15572-6.

PMID: # 11566882  Borodovsky, A. et al. 2001. EMBO J. 20: 5187-5196.

Citations 1 to 10 of 17 total
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