Ubiquitin Activating Enzyme UBE1 (rabbit)
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Application:
Ubiquitin Activating Enzyme UBE1 (rabbit) is a biochemical compound that catalyzes the activation of the C-terminal carboxyl group of ubiquitin
Molecular Weight:
~110 kDa
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
UBE1 is responsible for the first step in the ubiquitin-protein isopeptide bond formation. UBE1 catalyzes the activation of the C-terminal carboxyl group of ubiquitin by forming a high energy thioester bond. This activated ubiquitin is then transferred to the lysine of target proteins via the E2/E3 conjugation cascade. A critical component for the initiation of in vitro conjugation reactions.
Ubiquitin Activating Enzyme UBE1 (rabbit) References
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system: A. Ciechanover, et al.; PNAS 78, 761 (1981) Covalent affinity purification of ubiquitin-activating enzyme: A. Ciechanover, et al.; J. Biol. Chem. 257, 2537 (1982) The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis: A.L. Haas & I.A. Rose; J. Biol. Chem. 257, 10329 (1982)Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubiquitin Activating Enzyme UBE1 (rabbit), 25 µl | sc-222397 | 25 µl | $100.00 |