Ubiquitin (CAS 79586-22-4)
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Ubiquitin is a small, highly conserved protein found in all eukaryotic cells. It functions as a signal for targeting proteins for degradation by the proteasome, a large protein complex that degrades unneeded or damaged proteins in the cell. Ubiquitin is covalently attached to target proteins in a multi-step process that involves several enzymes, and this modification marks the protein for destruction by the proteasome. In addition to its role in protein degradation, ubiquitin has also been implicated in other cellular processes, such as DNA repair, signal transduction, and protein trafficking.
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Ubiquitin (CAS 79586-22-4) References
- The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. | Zhou, L. and Yang, H. 2011. PLoS One. 6: e23936. PMID: 21949687
- F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. | Liu, Y., et al. 2015. Cell Death Dis. 6: e1630. PMID: 25654763
- The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. | Liu, Y., et al. 2015. J Biol Chem. 290: 11843-52. PMID: 25778398
- Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. | Kharat, SS., et al. 2016. Oncogene. 35: 1025-38. PMID: 26028025
- Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). | Gilda, JE., et al. 2015. PLoS One. 10: e0135392. PMID: 26287535
- Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1. | Dove, KK., et al. 2017. Structure. 25: 890-900.e5. PMID: 28552575
- BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling. | Overlack, K., et al. 2017. Curr Biol. 27: 2915-2927.e7. PMID: 28943088
- The Monocot-Specific Receptor-like Kinase SDS2 Controls Cell Death and Immunity in Rice. | Fan, J., et al. 2018. Cell Host Microbe. 23: 498-510.e5. PMID: 29576481
- BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor. | Priyadarshini, R., et al. 2018. Cell Rep. 24: 947-961.e7. PMID: 30044990
- MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity. | Lee, IY., et al. 2019. Mol Cell. 73: 1138-1149.e6. PMID: 30901564
- Mechanistic Studies of the Multiple Myeloma and Melanoma Cell-Selective Toxicity of the Rpn13-Binding Peptoid KDT-11. | Dickson, P., et al. 2020. Cell Chem Biol. 27: 1383-1395.e5. PMID: 32857986
- Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL. | Hussain, M., et al. 2022. STAR Protoc. 3: 101710. PMID: 36136752
- Enhancing Biomolecule Analysis and 2DMS Experiments by Implementation of (Activated Ion) 193 nm UVPD on a FT-ICR Mass Spectrometer. | Theisen, A., et al. 2022. Anal Chem. 94: 15631-15638. PMID: 36317856
- LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus. | Wu, Z., et al. 2022. EMBO J. 41: e112006. PMID: 36398858
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubiquitin, 5 mg | sc-471120 | 5 mg | $159.00 |