UBE2Q2 Antibody (R-16): sc-100625

UBE2Q2 Antibody (R-16) is a mouse monoclonal IgG2a kappa light chain antibody that detects UBE2Q2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-UBE2Q2 antibody (R-16) is available as a non-conjugated format. UBE2Q2, or Ubiquitin-conjugating enzyme E2 Q2, is a 375 amino acid cytoplasmic protein that plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein turnover and maintaining cellular homeostasis. UBE2Q2 is primarily located in the cytoplasm, where UBE2Q2 facilitates the ubiquitination process by catalyzing the attachment of ubiquitin to target proteins, marking them for degradation. Proper functioning of UBE2Q2 is vital, as dysregulation of ubiquitination can lead to the accumulation of damaged or misfolded proteins, contributing to various diseases, including cancer. UBE2Q2 expression has been observed in invasive epithelial tissues and tumor masses, such as head and neck squamous cell carcinomas, indicating potential involvement in tumorigenesis. UBE2Q2 exists in two isoforms due to alternative splicing, which may further diversify functional roles in cellular processes.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

UBE2Q2 Antibody (R-16) References:

1. The maintenance of neuromuscular function requires UBC-25 in Caenorhabditis elegans.  |  Schulze, E., et al. 2003. Biochem Biophys Res Commun. 305: 691-9. PMID: 12763049
2. Differential expression of genes in the endometrium at implantation: upregulation of a novel member of the E2 class of ubiquitin-conjugating enzymes.  |  Melner, MH., et al. 2004. Biol Reprod. 70: 406-14. PMID: 14561654
3. Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway.  |  Zhang, YW., et al. 2005. Mol Cell. 19: 607-18. PMID: 16137618
4. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours.  |  Seghatoleslam, A., et al. 2006. Biochem Biophys Res Commun. 339: 422-9. PMID: 16300736
5. Demonstration of ubiquitin thiolester formation of UBE2Q2 (UBCi), a novel ubiquitin-conjugating enzyme with implantation site-specific expression.  |  Melner, MH., et al. 2006. Biol Reprod. 75: 395-406. PMID: 16760379
6. Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.  |  Banerjee, S., et al. 2007. Oncogene. 26: 6509-17. PMID: 17471241