UBE2O Antibody (2C10): sc-293246

UBE2O Antibody (2C10) is a mouse monoclonal IgG2a kappa light chain antibody that detects the UBE2O protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-UBE2O antibody (2C10) is available as a non-conjugated monoclonal isotype antibody. UBE2O, also known as ubiquitin-conjugating enzyme E2O or E2-230K, is a 1,292 amino acid protein that plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein degradation and maintaining cellular homeostasis. UBE2O is predominantly expressed in heart and skeletal muscle, where UBE2O catalyzes the ATP-dependent covalent attachment of ubiquitin to specific target proteins, marking them for proteasomal degradation. Proper functioning of UBE2O is vital, as UBE2O helps control the levels of various proteins involved in critical cellular processes, including cell cycle regulation and apoptosis. Dysregulation of UBE2O has been implicated in various diseases, including cancer, where accumulation of improperly regulated proteins can lead to uncontrolled cell growth. The gene encoding UBE2O is located on human chromosome 17, a region significant not only for its high gene density but also for its association with key tumor suppressor genes such as p53 and BRCA1, both integral to maintaining genomic stability and preventing tumorigenesis.

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UBE2O Antibody (2C10) References:

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8. UBE2O promotes hepatocellular carcinoma cell proliferation and invasion by regulating the AMPKα2/mTOR pathway.  |  Shi, Z., et al. 2021. Int J Med Sci. 18: 3749-3758. PMID: 34790050
9. UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair.  |  Huang, Q., et al. 2022. FASEB J. 36: e22112. PMID: 34921745
10. UBE2O ubiquitinates PTRF/CAVIN1 and inhibits the secretion of exosome-related PTRF/CAVIN1.  |  Cen, X., et al. 2022. Cell Commun Signal. 20: 191. PMID: 36443833
11. Age-Associated UBE2O Reduction Promotes Neuronal Death in Alzheimer's Disease.  |  Cheng, J., et al. 2023. J Alzheimers Dis. 93: 1083-1093. PMID: 37182872
12. UBE2O reduces the effectiveness of interferon-α via degradation of IFIT3 in hepatocellular carcinoma.  |  Li, H., et al. 2023. Cell Death Dis. 14: 854. PMID: 38129382