Molecular structure of U0124, CAS Number: 108923-79-1
U0124 (CAS 108923-79-1)
See product citations (3)
Alternate Names:
2,3-Bis-[1-amino-1-methylsulfanyl-meth-(Z)-ylidene]-succinonitrile; Bis[amino(methylthio)methylene]butanedinitrile
Application:
U0124 is an inactive analog of U0126 and a negative control
CAS Number:
108923-79-1
Molecular Weight:
226.31
Molecular Formula:
C8H10N4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U0124 is a potent and selective inhibitor of the protein kinase C (PKC) family. It is used to study the role of PKC in various cellular processes. U0124 effectively blocks the activation of PKC, which plays a role in signal transduction and the regulation of cell growth, differentiation, and apoptosis. By inhibiting PKC, U0124 can help better understanding the molecular mechanisms underlying these processes.
U0124 (CAS 108923-79-1) References
- Regulation of voltage-dependent calcium channels in rat sensory neurones involves a Ras-mitogen-activated protein kinase pathway. | Fitzgerald, EM. 2000. J Physiol. 527 Pt 3: 433-44. PMID: 10990531
- ERK1/2 mediates TNF-alpha-induced matrix metalloproteinase-9 expression in human vascular smooth muscle cells via the regulation of NF-kappaB and AP-1: Involvement of the ras dependent pathway. | Moon, SK., et al. 2004. J Cell Physiol. 198: 417-27. PMID: 14755547
- Mitogen-activated protein kinase (MAPK) blockade of bovine preimplantation embryogenesis requires inhibition of both p38 and extracellular signal-regulated kinase (ERK) pathways. | Madan, P., et al. 2005. Reproduction. 130: 41-51. PMID: 15985630
- Inhibition of extracellular signal-regulated kinase 1/2 augments nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells. | Koide, N., et al. 2005. FEMS Immunol Med Microbiol. 45: 213-9. PMID: 16051071
- Neural induction in the absence of organizer in salamanders is mediated by MAPK. | Hurtado, C. and De Robertis, EM. 2007. Dev Biol. 307: 282-9. PMID: 17540356
- A mitogen-activated protein kinase signals to programmed cell death induced by self-incompatibility in Papaver pollen. | Li, S., et al. 2007. Plant Physiol. 145: 236-45. PMID: 17660353
- Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. | Aomatsu, K., et al. 2008. Immunology. 123: 171-80. PMID: 17662043
- PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. | Fu, Y., et al. 2008. Mol Pain. 4: 26. PMID: 18631385
- Oestrogen increases nociception through ERK activation in the trigeminal ganglion: evidence for a peripheral mechanism of allodynia. | Liverman, CS., et al. 2009. Cephalalgia. 29: 520-31. PMID: 19210515
- Organ culture of the trigeminal ganglion induces enhanced expression of calcitonin gene-related peptide via activation of extracellular signal-regulated protein kinase 1/2. | Tajti, J., et al. 2011. Cephalalgia. 31: 95-105. PMID: 20851839
- Induction of neuritogenesis in PC12 cells by a pulsed electromagnetic field via MEK-ERK1/2 signaling. | Kudo, TA., et al. 2013. Cell Struct Funct. 38: 15-20. PMID: 23318214
- Induction of neurite outgrowth in PC12 cells treated with temperature-controlled repeated thermal stimulation. | Kudo, TA., et al. 2015. PLoS One. 10: e0124024. PMID: 25879210
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U0124, 10 mg | sc-204934 | 10 mg | $165.00 |