Date published: 2025-9-5

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U 92016A Hydrochloride (CAS 149654-41-1)

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Alternate Names:
(8R)-8-(Dipropylamino)-6,7,8,9-tetrahydro-3H-benzo[e]indole-2-carbonitrile hydrochloride (1:1)
Application:
U 92016A is a selective SR-1A agonist
CAS Number:
149654-41-1
Purity:
≥99%
Molecular Weight:
331.88
Molecular Formula:
C19H25N3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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U 92016A is a compound of interest within the realm of neuroscientific research, where it is studied for its potential effects on neurotransmitter systems. Specifically, it is examined for its role as a modulator of glutamate receptors, which are pivotal in synaptic transmission and plasticity in the central nervous system. U 92016A is used to investigate the intricacies of excitatory signal transduction and its implications for learning and memory processes. The compound′s interaction with the glutamatergic system also makes it useful for understanding the pathophysiology of neurological conditions associated with glutamate dysfunction. Additionally, U 92016A is utilized in assays to study neuroprotection and to explore the cellular and molecular mechanisms that could be involved in neurodegenerative diseases.


U 92016A Hydrochloride (CAS 149654-41-1) References

  1. Molecular, pharmacological and functional diversity of 5-HT receptors.  |  Hoyer, D., et al. 2002. Pharmacol Biochem Behav. 71: 533-54. PMID: 11888546
  2. Molecular pathopharmacology of 5-HT2C receptors and the RNA editing in the brain.  |  Tohda, M., et al. 2006. J Pharmacol Sci. 100: 427-32. PMID: 16799258
  3. 5-hydroxtryptamine receptors in systemic hypertension: an arterial focus.  |  Watts, SW. and Davis, RP. 2011. Cardiovasc Ther. 29: 54-67. PMID: 20433685
  4. Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster.  |  Johnson, O., et al. 2011. Neuroscience. 192: 372-81. PMID: 21749913
  5. Modulation of the immune response by helminths: a role for serotonin?  |  Wang, SJ., et al. 2018. Biosci Rep. 38: PMID: 30177522
  6. An Unbiased Drug Screen for Seizure Suppressors in Duplication 15q Syndrome Reveals 5-HT1A and Dopamine Pathway Activation as Potential Therapies.  |  Roy, B., et al. 2020. Biol Psychiatry. 88: 698-709. PMID: 32507391
  7. Xiaoxuming Decoction Regulates Vascular Function by Modulating G Protein-Coupled Receptors: A Molecular Docking Study.  |  Shen, Y., et al. 2021. Biomed Res Int. 2021: 5575443. PMID: 34195269
  8. Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist.  |  McCall, RB., et al. 1994. J Pharmacol Exp Ther. 271: 875-83. PMID: 7965808
  9. Novel 2-substituted tetrahydro-3H-benz[e]indolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants.  |  Romero, AG., et al. 1993. J Med Chem. 36: 2066-74. PMID: 8101876

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

U 92016A Hydrochloride, 5 mg

sc-204363
5 mg
$260.00

U 92016A Hydrochloride, 50 mg

sc-204363A
50 mg
$974.00

U 92016A Hydrochloride, 1 g

sc-204363B
1 g
$79.00