Molecular structure of U 89843A, CAS Number: 157013-85-9
U 89843A (CAS 157013-85-9)
Alternate Names:
6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
Application:
U 89843A is a positive allosteric modulator of GABAA receptors
CAS Number:
157013-85-9
Molecular Weight:
321.85
Molecular Formula:
C16H23N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Positive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
U 89843A (CAS 157013-85-9) References
- On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics. | Kalgutkar, AS., et al. 2002. Curr Drug Metab. 3: 379-424. PMID: 12093357
- Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function. | McBrinn, RC., et al. 2019. Br J Pharmacol. 176: 4521-4536. PMID: 31368510
- U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. | Im, HK., et al. 1995. J Pharmacol Exp Ther. 275: 1390-5. PMID: 8531107
- In vitro and in vivo biotransformation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-D]pyrimidine (U-89843) in the rat. | Zhao, Z., et al. 1996. Drug Metab Dispos. 24: 187-98. PMID: 8742230
- Neuroprotective efficacy of microvascularly-localized versus brain-penetrating antioxidants. | Hall, ED., et al. 1996. Acta Neurochir Suppl. 66: 107-13. PMID: 8780807
- Bioactivation of 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843) to reactive intermediates that bind covalently to macromolecules and produce genotoxicity. | Zhao, Z., et al. 1996. Chem Res Toxicol. 9: 1230-9. PMID: 8951224
- Pyrrolopyrimidines: novel brain-penetrating antioxidants with neuroprotective activity in brain injury and ischemia models. | Hall, ED., et al. 1997. J Pharmacol Exp Ther. 281: 895-904. PMID: 9152399
- Superior neuroprotective efficacy of a novel antioxidant (U-101033E) with improved blood-brain barrier permeability in focal cerebral ischemia. | Schmid-Elsaesser, R., et al. 1997. Stroke. 28: 2018-24. PMID: 9341713
- Contribution of serum protein association to discrepancy between the in vivo and in vitro UDS results for 6,7-dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine (U-89843). | Zhao, Z., et al. 1997. Mutat Res. 395: 119-26. PMID: 9465922
Activator of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U 89843A, 10 mg | sc-204361 | 10 mg | $125.00 | |||
U 89843A, 50 mg | sc-204361A | 50 mg | $525.00 |