Molecular structure of U-83836E, CAS Number: 122003-11-6
U-83836E (CAS 122003-11-6)
See product citations (1)
Alternate Names:
(-)2-((4-(2,6-di-1-Pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)methyl)-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol dihydrochloride
Application:
U-83836E is an agent that prevents hydrogen peroxide-induced F2 isoprostane production
CAS Number:
122003-11-6
Purity:
98%
Molecular Weight:
593.6
Molecular Formula:
C30H44N6O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-83836E prevents hydrogen peroxide-induced F2 isoprostane production in renal proximal tubular cells, prevents free radical mediated effects of oxyhemoglobin in vascular smooth muscle, and reduces secondary brain injury in a rabbit model of cryogenic trauma. Research shows that U-83836E improves survival of rat embryonic mesencephalic tissue stored at 4C, and mitigates the toxicity of methanol on the antioxidant system of the rat brain. Western blot of cardiac tissue pretreated with U-83836E shows increase expression of HSP 70 (HSP72).
U-83836E (CAS 122003-11-6) References
- N-acetylcysteine or trolox derivative mitigate the toxic effects of methanol on the antioxidant system of rat brain. | Farbiszewski, R., et al. 2000. Toxicology. 156: 47-55. PMID: 11162875
- Lazaroid U-83836E improves tolerance to hemorrhagic shock and limb ischemia and reperfusion in rats and increases cardiac heat shock protein 72. | Labruto, F., et al. 2006. Acad Emerg Med. 13: 7-12. PMID: 16365323
- Effects of U83836E on nerve functions, hyperalgesia and oxidative stress in experimental diabetic neuropathy. | Sayyed, SG., et al. 2006. Life Sci. 79: 777-83. PMID: 16581090
- In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. | Vignes, JR. and Hugon, J. 2006. Neurosci Lett. 407: 171-5. PMID: 16973271
- Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways. | Yang, C., et al. 2008. Am J Physiol Regul Integr Comp Physiol. 294: R467-76. PMID: 18046016
- Mitochondrial protection after traumatic brain injury by scavenging lipid peroxyl radicals. | Mustafa, AG., et al. 2010. J Neurochem. 114: 271-80. PMID: 20403083
- Reactive oxygen species and lipid peroxidation inhibitors reduce mechanical sensitivity in a chronic neuropathic pain model of spinal cord injury in rats. | Hassler, SN., et al. 2014. J Neurochem. 131: 413-7. PMID: 25051888
- The 4-hydroxynonenal mediated oxidative damage of blood proteins and lipids involves secondary lipid peroxidation reactions. | Mustafa, AG., et al. 2018. Exp Ther Med. 16: 2132-2137. PMID: 30186450
- Scavenging of lipid peroxyl radicals protects plasma lipids and proteins from peroxynitrite. | Mustafa, AG., et al. 2018. Biomed Rep. 9: 421-426. PMID: 30345039
- U83836E reduces secondary brain injury in a rabbit model of cryogenic trauma. | Wilson, JT., et al. 1995. J Trauma. 39: 473-7; discussion 477-9. PMID: 7473911
- Lazaroids and deferoxamine attenuate the intracellular effects of oxyhaemoglobin in vascular smooth muscle. | Vollrath, B., et al. 1995. Cardiovasc Res. 30: 619-26. PMID: 8575010
- Hydrogen peroxide induces 21-aminosteroid-inhibitable F2-isoprostane production and cytolysis in renal tubular epithelial cells. | Salahudeen, A., et al. 1995. J Am Soc Nephrol. 6: 1300-3. PMID: 8589301
- The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation. | Grasbon-Frodl, EM., et al. 1996. Brain Res Bull. 39: 341-7. PMID: 9138743
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-83836E, 100 mg | sc-200805 | 100 mg | $109.00 |