Molecular structure of U 82836E, CAS Number: 137018-55-4
U 82836E (CAS 137018-55-4)
Alternate Names:
PNU-83836E
Application:
U 82836E is an iron-dependent lipid peroxidation inhibitor
CAS Number:
137018-55-4
Purity:
≥98%
Molecular Weight:
593.63
Molecular Formula:
C30H44N6O2•2HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
U 82836E is a free radical scavenger and antioxidant which becomes cytotoxic at higher concentrations. It is a second-generation lazaroid inhibitor of iron-dependent lipid peroxidation in rat brain cells (IC50 = 0.6 muM). U 82836E shows neuroprotective activity in a mouse head injury model (MHI) and causes a reduction in cyanide-induced cell death in rat cortical neurons. At higher concentrations, however, U 82836E may act to reduce the viability of rat brain endothelial cells (RBE4, IC50 = 0.032 mM).
U 82836E (CAS 137018-55-4) References
- A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. | Sparrow, JR., et al. 2003. J Biol Chem. 278: 18207-13. PMID: 12646558
- 2-(Aminomethyl)chromans that inhibit iron-dependent lipid peroxidation and protect against central nervous system trauma and ischemia. | Jacobsen, EJ., et al. 1992. J Med Chem. 35: 4464-72. PMID: 1447746
- In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia. | Vignes, JR. and Hugon, J. 2006. Neurosci Lett. 407: 171-5. PMID: 16973271
- Inhibition of tumour necrosis factor and reversal of endotoxin-induced shock by U-83836E, a 'second generation' lazaroid in rats. | Altavilla, D., et al. 1998. Br J Pharmacol. 124: 1293-9. PMID: 9720803
Inhibitor of:
Apoptosis, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U 82836E, 25 mg | sc-204360 | 25 mg | $31.00 | |||
U 82836E, 50 mg | sc-204360A | 50 mg | $56.00 | |||
U 82836E, 100 mg | sc-204360B | 100 mg | $134.00 | |||
U 82836E, 1 g | sc-204360C | 1 g | $1040.00 |