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U-75302 (CAS 119477-85-9)

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Application:
U-75302 is a selective leukotriene B4 antagonist
CAS Number:
119477-85-9
Purity:
≥98%
Molecular Weight:
361.5
Molecular Formula:
C22H35NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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U-75302 is a compound of interest in various fields of biochemical research, particularly in the study of lipid signaling pathways and inflammation. As a molecule that has been implicated in the modulation of leukotriene activity, U-75302 is valuable in exploring the intricacies of inflammatory responses at the cellular level. Researchers utilize this compound to probe the function of leukotriene receptors and the downstream signaling events they initiate, which are critical for the body′s response to injury and infection. U-75302 is also employed as a tool to dissect the roles of eicosanoids, a broader class of signaling molecules, in maintaining physiological homeostasis and their involvement in pathological conditions. In addition, it is studied for its interaction with enzymes such as lipoxygenases, which are key in the metabolism of polyunsaturated fatty acids.


U-75302 (CAS 119477-85-9) References

  1. Characterization of the cloned guinea pig leukotriene B4 receptor: comparison to its human orthologue.  |  Boie, Y., et al. 1999. Eur J Pharmacol. 380: 203-13. PMID: 10513580
  2. A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders.  |  Yokomizo, T., et al. 2000. J Exp Med. 192: 421-32. PMID: 10934230
  3. Leukotrienes modulate cytokine release from dendritic cells.  |  Jozefowski, S., et al. 2005. Immunology. 116: 418-28. PMID: 16313356
  4. Contribution of leukotriene B4 to airway inflammation and the effect of antagonists.  |  Richards, IM., et al. 1991. Ann N Y Acad Sci. 629: 274-87. PMID: 1659282
  5. Effect of the selective leukotriene B4 antagonists U-75302 and Ly255283 on bronchoalveolar eosinophilia induced by inhalation of leukotriene B4 or allergen in brown-Norway rats.  |  Richards, IM., et al. 1991. Ann N Y Acad Sci. 629: 428-9. PMID: 1659288
  6. Leukotriene B4 regulates proliferation and differentiation of cultured rat myoblasts via the BLT1 pathway.  |  Sun, R., et al. 2009. Mol Cells. 27: 403-8. PMID: 19390820
  7. 5-lipoxygenase activating protein signals adipose tissue inflammation and lipid dysfunction in experimental obesity.  |  Horrillo, R., et al. 2010. J Immunol. 184: 3978-87. PMID: 20207999
  8. [Involvement of leukotrine B4 receptors in the inflammatory responses and immunological regulation in vitro].  |  Han, CG., et al. 2009. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 25: 273-6. PMID: 21189570
  9. Proteinase-activated receptor-4 plays a major role in the recruitment of neutrophils induced by trypsin or carrageenan during pleurisy in mice.  |  Gomides, LF., et al. 2012. Pharmacology. 89: 275-82. PMID: 22517275
  10. Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B₄-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1.  |  Fernandes, ES., et al. 2013. FASEB J. 27: 1664-73. PMID: 23271050
  11. Effect of the selective leukotriene B4 antagonist U-75302 on antigen-induced bronchopulmonary eosinophilia in sensitized guinea pigs.  |  Richards, IM., et al. 1989. Am Rev Respir Dis. 140: 1712-6. PMID: 2557787
  12. Receptor antagonism of leukotriene B4 myotropic activity by the 2,6 disubstituted pyridine analog U-75302: characterization on lung parenchyma strips.  |  Lawson, CF., et al. 1989. J Lipid Mediat. 1: 3-12. PMID: 2562431
  13. Leukotrienes and their antagonists in allergic disorders.  |  Negro, JM., et al. 1997. Allergol Immunopathol (Madr). 25: 104-12. PMID: 9150842

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

U-75302, 100 µg

sc-201331
100 µg
$296.00