U-698-M Whole Cell Lysate: sc-364799

U-698-M Whole Cell Lysate is derived from U-698-M cells, a human acute lymphoblastic leukemia (ALL) cell line originally established from the peripheral blood of a patient with T-cell ALL. This lysate is extensively used in hematological research to study the molecular mechanisms underlying T-cell leukemia. U-698-M cells exhibit characteristic genetic alterations, including rearrangements in the T-cell receptor genes, making the lysate valuable for analyzing signaling pathways and gene expression involved in leukemogenesis. Researchers utilize U-698-M Whole Cell Lysate to investigate the activation states, expression, and interactions of key proteins involved in T-cell signaling pathways, such as JAK/STAT, Notch, and NF-κB, using techniques like western blotting, immunoprecipitation, and mass spectrometry. This lysate is particularly useful for examining the effects of various cytokines and growth factors on T-cell proliferation and differentiation. Additionally, it aids in exploring the molecular basis of apoptosis resistance and chemoresistance in T-cell leukemia by studying the roles of anti-apoptotic proteins and drug efflux pumps. By comparing U-698-M lysates with those from normal T cells, scientists can identify specific molecular alterations associated with T-cell leukemia, providing insights into the cellular processes that drive leukemogenesis and offering a valuable resource for advancing research in leukemia biology and signal transduction.