U-46619 Glycine methyl ester
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A stable analog of the endoperoxide PGH2, and a TP receptor agonist.1 Exhibits properties similar to TXA2, causing platelet shape change, aggregation, and contraction of vascular smooth muscle.2,3 Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation, are 82, 145, and 65 nM, respectively.4 Contains a modification at the C-1 position of U-46619 that may uniquely alter its binding properties to the TP receptor or any of the PGH2-metabolizing enzymes. As a stable PGH2 analog, it could be a useful tool to explore the inhibition of various enzymes in the arachidonic acid metabolic pathway. Also may serve as a lipophilic prodrug form of U-46619 that will alter its distribution and pharmacokinetic properties.
U-46619 Glycine methyl ester References
1 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000). 2 Coleman, R.A., Humphrey, P.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-46619 Glycine methyl ester, 50 µg | sc-224337 | 50 µg | $70.00 | |||
U-46619 Glycine methyl ester, 100 µg | sc-224337A | 100 µg | $134.00 |