Molecular structure of U-46619, CAS Number: 56985-40-1
U-46619 (CAS 56985-40-1)
See product citations (40)
Alternate Names:
U-46619 is also known as Thromboxane A2 agonist.
Application:
U-46619 is a stable thromboxane A2 mimetic and analog of the H2 endoperoxide prostaglandin, used as a vasoconstrictor and thromboxane receptor agonist.
CAS Number:
56985-40-1
Purity:
≥98%
Molecular Weight:
350.49
Molecular Formula:
C21H34O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-46619, a prostaglandin H2 analogue, may act to be a potent agonist of thromboxane A2 and also can cause constriction of coronary arteries. U-46619 has been reported to inhibit platelet-rich plasma aggregation. Mechanistic studies suggest that U-46619 binds to the putative human platelet TXA2R/PGH2 receptor. Once bound, U-46619 activates TXA2Rs and inhibits the release of hippocampal noradrenaline. U-46619 exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. U-46619 is also known as 9,11-dideoxy-9α,11α-methanoepoxy-prosta-5Z,13E-dien-1-oic acid, 9,11-dideoxy-9α,11α-methanoepoxy Prostaglandin F2α, and 9,11-dideoxy-9α,11α-methanoepoxy PGF2α.
U-46619 (CAS 56985-40-1) References
- Prostanoids and related compounds. VII. Synthesis and inhibitory activity of 1-isoindolinone derivatives possessing inhibitory activity against thromboxane A2 analog (U-46619)-induced vasoconstriction. | Kato, Y., et al. 1999. Chem Pharm Bull (Tokyo). 47: 529-35. PMID: 10319431
- U-46619, a selective thromboxane A2 mimetic, inhibits the release of endogenous noradrenaline from the rat hippocampus in vitro. | Nishihara, M., et al. 2000. Jpn J Pharmacol. 82: 226-31. PMID: 10887953
- Binding of a thromboxane A2/prostaglandin H2 agonist [3H]U46619 to washed human platelets. | Liel, N., et al. 1987. Prostaglandins. 33: 789-97. PMID: 2959986
- Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa. | Esplugues, JV. and Whittle, BJ. 1988. Prostaglandins. 35: 137-48. PMID: 2966419
- Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo. | Whittle, BJ., et al. 1985. Am J Physiol. 248: G580-6. PMID: 2986466
- Responses of cerebral arterioles to adenosine 5'-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension. | Mayhan, WG., et al. 1988. Hypertension. 12: 556-61. PMID: 3203960
- Stimulation of glycogenolysis and vasoconstriction in the perfused rat liver by the thromboxane A2 analogue U-46619. | Fisher, RA., et al. 1987. J Biol Chem. 262: 4631-8. PMID: 3558359
- Thromboxane A2 analogue (U-46619) stimulates vascular PGI2 synthesis. | Jeremy, JY., et al. 1985. Eur J Pharmacol. 107: 259-62. PMID: 3884343
- Responsiveness of platelets and coronary arteries from different species to synthetic thromboxane and prostaglandin endoperoxide analogues. | Burke, SE., et al. 1983. Br J Pharmacol. 78: 287-92. PMID: 6831115
- Comparison of the actions of U-46619, a prostaglandin H2-analogue, with those of prostaglandin H2 and thromboxane A2 on some isolated smooth muscle preparations. | Coleman, RA., et al. 1981. Br J Pharmacol. 73: 773-8. PMID: 7248665
- Time-dependent inhibition by glyceryl trinitrate of platelet aggregation caused by U46619 (a thromboxane/endoperoxide receptor agonist). | Kampf, G. and Ritter, JM. 1994. Br J Clin Pharmacol. 38: 80-2. PMID: 7946941
- The thromboxane mimetic, U-46619, induces the aggregation of fish thrombocytes. | Hill, DJ. and Rowley, AF. 1996. Br J Haematol. 92: 200-11. PMID: 8562396
- The thromboxane A2 mimetic U-46619 inhibits somatomotor activity via a vagal reflex from the lung. | Pickar, JG. 1998. Am J Physiol. 275: R706-12. PMID: 9728066
Inhibitor of:
IP Receptor.Activator of:
γ-FR, 4931406P16Rik, 4931417E11Rik, aC1, ARHGEF5_Arhgef5, BLC, BST-1, CD32-A_Fc γ RIII, CD42a, CD42b, CD42c, CD42d, CD97, CLEC-2F, CLEC-2G, CysLT1 Receptor, ERK 1, ERK 2, FGD2, FGD5, GPVI, group V PLA2, Integrin αIIb, MAS1L, MIP-1b, MRVI1a, Multimerin-2, MYL9, NK10, p38, PECAM-1, PF-4, Rock-1, smoothelin, TG1019, TXA2R, and VCAM-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-46619, 1 mg | sc-201242 | 1 mg | $240.00 | |||
U-46619, 10 mg | sc-201242A | 10 mg | $1275.00 |