U-2 OS Cell Lysate: sc-2295

U-2 OS is a cell line derived from from a sarcoma of the tibia of a 15-year-old, female osteosarcoma patient. This lysate is extensively used in cancer research to study the molecular mechanisms underlying osteosarcoma, a type of bone cancer. U-2 OS cells exhibit characteristic genetic and epigenetic alterations, including mutations in the TP53 gene and overexpression of oncogenes such as c-Myc, making the lysate valuable for analyzing signaling pathways involved in tumor growth, survival, and metastasis. Researchers utilize U-2 OS Cell Lysate to investigate the expression, phosphorylation, and interaction of key proteins involved in pathways like PI3K/AKT, Wnt/β-catenin, and MAPK/ERK using techniques such as western blotting, immunoprecipitation, and mass spectrometry. This lysate aids in exploring the molecular basis of osteosarcoma cell proliferation, migration, and invasion by examining the roles of cell cycle regulators, matrix metalloproteinases, and adhesion molecules. Additionally, U-2 OS Cell Lysate is employed to study the effects of various chemical compounds on these signaling pathways, providing insights into the cellular processes that drive osteosarcoma progression. By comparing U-2 OS lysates with those from normal osteoblasts, scientists can identify specific molecular alterations associated with osteosarcoma, advancing research in cancer biology and signal transduction.

U-2 OS Cell Lysate References:

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