Molecular structure of U-0521, CAS Number: 5466-89-7
U-0521 (CAS 5466-89-7)
Application:
U-0521 is an extraneuronal COMT uptake inhibitor
CAS Number:
5466-89-7
Purity:
98%
Molecular Weight:
180.2
Molecular Formula:
C10H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
U-0521 is an extraneuronal COMT (Catechol-O-methyltransferase) uptake inhibitor. This may act to decrease contractile responses in rat vas deferens. U-0521 is a potent inhibitor of catechol-O-methyltransferase (COMT), with the primary effect of increasing the accessibility and utilization of levodopa within the brain. By specifically targeting and inhibiting the activity of catechol-O-methyltransferase, U-0521 plays a role in enhancing the efficacy of levodopa.
U-0521 (CAS 5466-89-7) References
- Altered inotropic and chronotropic effects of noradrenaline on isolated rat atria exposed to chagasic sera. Influences of cocaine, normetanephrine and U-0521 (3'-4'-dihydroxy-2-methyl propiophenone. | Gimeno, AL., et al. 1979. Cardiovasc Res. 13: 723-31. PMID: 119577
- Activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (U-0521). | Kaumann, AJ., et al. 1977. Naunyn Schmiedebergs Arch Pharmacol. 296: 217-28. PMID: 14306
- Altered metabolism of [18F]-6-fluorodopa in the hooded rat following inhibition of catechol-O-methyltransferase with U-0521. | Cumming, P., et al. 1987. Biochem Pharmacol. 36: 2527-31. PMID: 3111485
- Age-related changes in guinea pig respiratory tissues: considerations for assessment of bronchodilators. | Duncan, PG. and Douglas, JS. 1985. Eur J Pharmacol. 108: 39-48. PMID: 3979434
- Comparison of the effects of tropolone, beta-thujaplicin and U-0521 on the extraneuronal accumulation of isoprenaline in guinea-pig trachealis smooth muscle cells. A quantitative fluorescence histochemical study. | Bryan, LJ. and O'Donnell, SR. 1979. Naunyn Schmiedebergs Arch Pharmacol. 307: 235-41. PMID: 492345
- The catechol-O-methyl transferase activity and endogenous catecholamine content of various tissues in the rat and the effect of administration of U-0521 (3',4'-dihydroxy-2-methyl propiophenone). | Giles, RE. and Miller, JW. 1967. J Pharmacol Exp Ther. 158: 189-94. PMID: 5625691
- A comparison of 2-hydroxyestradiol and U-0521 (3'4'-dihydroxy-2-methylpropiophenone, Upjohn) as in situ and in vitro inhibitors of tyrosine hydroxylase. | Lloyd, T., et al. 1982. J Neurochem. 38: 948-54. PMID: 6121005
- Catechol-O-methyltransferase and Parkinson's disease. | Reches, A. and Fahn, S. 1984. Adv Neurol. 40: 171-9. PMID: 6695593
- A comparative study of the properties of the catechol-O-methyltransferase inhibitors, U-0521 and tropolone acetamide, in rat perfused heart. | Bryan, LJ., et al. 1983. Naunyn Schmiedebergs Arch Pharmacol. 322: 6-19. PMID: 6843690
- Catechol-O-methyltransferase inhibition by U-0521 increases striatal utilization of levodopa. | Reches, A., et al. 1982. Naunyn Schmiedebergs Arch Pharmacol. 320: 34-7. PMID: 7121609
- Effect of 3',4'-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. | Reches, A., et al. 1982. Biochem Pharmacol. 31: 3415-8. PMID: 7150363
- The antihypertensive effect of U-0521 (3',4'-dihydroxy-2-methylpropiophenone). | Lloyd, T. and Waldman, CD. 1982. Life Sci. 31: 2121-7. PMID: 7176811
- Extraneuronal uptake inhibitor U-0521 decreases contractile responses in rat vas deferens. | Rice, PJ., et al. 1997. Gen Pharmacol. 29: 437-9. PMID: 9378252
Inhibitor of:
COMT.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
U-0521, 20 mg | sc-200745 | 20 mg | $120.00 | |||
U-0521, 100 mg | sc-200745A | 100 mg | $306.00 |