Molecular structure of Tyvelose, CAS Number: 5658-12-8
Tyvelose (CAS 5658-12-8)
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Alternate Names:
3,6-Dideoxy-D-arabino-hexose; 3,6-Dideoxy-D-mannose; D-Tyvelose
Application:
Tyvelose is an immunomodulatory compound found in T. spiralis glycoprotein antigens
CAS Number:
5658-12-8
Molecular Weight:
148.16
Molecular Formula:
C6H12O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyvelose is the immunodominant portion of the major larval glycoprotein antigens of Trichinella spiralis, which play an important role in generating immunity against the intestinal stages of infection. Tyvelose is made up of three constituents: 3,6-dideoxy-D-glycero-hexose and two fatty acids. The chemical composition of Tyvelose has been determined through chemical synthesis and spectroscopic analysis. Additionally, it is used in the biosynthesis of the lipid A antigen present on gram-negative bacteria.
Tyvelose (CAS 5658-12-8) References
- Antibodies to tyvelose exhibit multiple modes of interference with the epithelial niche of Trichinella spiralis. | McVay, CS., et al. 2000. Infect Immun. 68: 1912-8. PMID: 10722582
- Possible presence of common tyvelose-containing glycans in Trichinella L1 larvae and embryonated eggs of several nematodes. | Dea-Ayuela, MA., et al. 2001. Parasite. 8: S120-2. PMID: 11484333
- Tyvelose and protective responses to the intestinal stages of Trichinella spiralis. | Goyal, PK., et al. 2002. Parasitol Int. 51: 91-8. PMID: 11880231
- High resolution x-ray structure of tyvelose epimerase from Salmonella typhi. | Koropatkin, NM., et al. 2003. J Biol Chem. 278: 20874-81. PMID: 12642575
- THE ENZYMATIC SYNTHESIS OF CYTIDINE DIPHOSPHATE TYVELOSE. | ELBEIN, AD. 1965. Proc Natl Acad Sci U S A. 53: 803-6. PMID: 14324537
- Intermolecular cooperativity: a clue to why mice have IgG3? | Greenspan, NS. and Cooper, LJ. 1992. Immunol Today. 13: 164-8. PMID: 1642754
- The mouse antibody response to Trichinella spiralis defines a single, immunodominant epitope shared by multiple antigens. | Denkers, EY., et al. 1990. J Immunol. 144: 3152-9. PMID: 1691229
- Structure and gene cluster of a tyvelose-containing O-polysaccharide of an entomopathogenic bacterium Yersinia entomophaga MH96T related to Yersinia pseudotuberculosis. | Sizova, OV., et al. 2017. Carbohydr Res. 445: 93-97. PMID: 28460348
- Expanding the Enzyme Repertoire for Sugar Nucleotide Epimerization: The CDP-Tyvelose 2-Epimerase from Thermodesulfatator atlanticus for Glucose/Mannose Interconversion. | Rapp, C., et al. 2021. Appl Environ Microbiol. 87: PMID: 33277270
- Biosynthesis of tyvelose. The purification and properties of cytidine diphosphate D-glucose oxidoreductase. | Hey, AE. and Elbein, AD. 1966. J Biol Chem. 241: 5473-8. PMID: 4380946
- Novel tyvelose-containing tri- and tetra-antennary N-glycans in the immunodominant antigens of the intracellular parasite Trichinella spiralis. | Reason, AJ., et al. 1994. Glycobiology. 4: 593-603. PMID: 7881173
- Synthesis and conformational studies of the tyvelose capped, Lewis-x like tetrasaccharide epitope of Trichinella spiralis. | Zhang, J., et al. 1996. Bioorg Med Chem. 4: 1989-2001. PMID: 9007282
- Workshop on a detailed characterization of Trichinella spiralis antigens: a platform for future studies on antigens and antibodies to this parasite. | Ortega-Pierres, MG., et al. 1996. Parasite Immunol. 18: 273-84. PMID: 9229380
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyvelose, 10 mg | sc-222394 | 10 mg | $380.00 | |||
Tyvelose, 25 mg | sc-222394A | 25 mg | $672.00 | |||
Tyvelose, 100 mg | sc-222394B | 100 mg | $2244.00 |