Molecular structure of Tyrphostin AG 99, CAS Number: 118409-59-9
Tyrphostin AG 99 (CAS 118409-59-9)
Alternate Names:
Tyrphostin A46; Tyrphostin 46; AG 99; (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenamide
Application:
Tyrphostin AG 99 is a potent, cell-permeable and reversible inhibitor of EGFR and EGF-dependent cell proliferation
CAS Number:
118409-59-9
Purity:
>98%
Molecular Weight:
204.18
Molecular Formula:
C10H8N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyrphostin AG 99 is a potent, cell-permeable, reversible inhibitor of EGFR (epidermal growth factor receptor) and EGF-dependent cell proliferation. Stimulation of EGFRs result in tumor growth and proliferation, inhibition of apoptosis, stimulation of angiogenesis and the promotion of tissue invasion and metastasis. Tyrphostin AG 99 may act to inhibit EGFR phosphorylation and ERK1 and ERK2 activities.
Tyrphostin AG 99 (CAS 118409-59-9) References
- Inhibition of volume-stimulated taurine efflux and tyrosine kinase activity in the skate red blood cell. | Hubert, EM., et al. 2000. Pflugers Arch. 440: 132-9. PMID: 10864006
- Clastogenic effects of two tyrosine kinase inhibitors, tyrphostin 23 and tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic chinese hamster cell line (CHE). | Bassi, L., et al. 2000. Mutagenesis. 15: 341-7. PMID: 10887214
- Role of leptin in ulcer healing. | Konturek, PC., et al. 2001. Eur J Pharmacol. 414: 87-97. PMID: 11230999
- Infection with Campylobacter jejuni induces tyrosine-phosphorylated proteins into INT-407 cells. | Biswas, D., et al. 2004. Microbiol Immunol. 48: 221-8. PMID: 15107531
- Extracellular signal regulated kinase and SMAD signaling both mediate the angiotensin II driven progression towards overt heart failure in homozygous TGR(mRen2)27. | de Boer, RA., et al. 2004. J Mol Med (Berl). 82: 678-87. PMID: 15322702
- Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat. | Ancha, HR., et al. 2006. Dig Dis Sci. 51: 274-81. PMID: 16534669
- Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases. | Gazit, A., et al. 1991. J Med Chem. 34: 1896-907. PMID: 1676428
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- Interaction of epidermal growth factor with COX-2 products and peroxisome proliferator-activated receptor-γ system in experimental rat Barrett's esophagus. | Majka, J., et al. 2020. Am J Physiol Gastrointest Liver Physiol. 318: G375-G389. PMID: 31928220
- Lipopolysaccharide inhibits in vitro luteinizing hormone-stimulated rat ovarian granulosa cell estradiol but not progesterone secretion. | Taylor, CC. and Terranova, PF. 1996. Biol Reprod. 54: 1390-6. PMID: 8724369
- In vitro demonstration of a mitogenic activity in renal tissue extracts during regenerative hyperplasia. | Piron, A., et al. 1998. Am J Physiol. 274: F348-57. PMID: 9486230
- Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. | Pai, R., et al. 1998. Gastroenterology. 114: 706-13. PMID: 9516391
- Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. | Martin, BL. 1998. Biochem Pharmacol. 56: 483-8. PMID: 9763224
Inhibitor of:
Apoptosis, and EGFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin AG 99, 5 mg | sc-202847 | 5 mg | $55.00 | |||
Tyrphostin AG 99, 25 mg | sc-202847A | 25 mg | $188.00 |