Molecular structure of Tyrphostin AG 957, CAS Number: 140674-76-6
Tyrphostin AG 957 (CAS 140674-76-6)
Alternate Names:
methyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate; Lavendustin C Analog
Application:
Tyrphostin AG 957 is a potent tyrosine kinase inhibitor
CAS Number:
140674-76-6
Molecular Weight:
273.28
Molecular Formula:
C15H15NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyrphostin AG 957 is a potent tyrosine kinase inhibitor. Selectively blocks the tyrosine kinase activity of human p210bcr-abl (Ki = 750 nM) over p140c-abl (Ki = 10 µM). Also decreases p210bcr-abl phosphorylation in viable K562 cells at concentrations and durations of exposure that also inhibit cell proliferation. Reported to alter the physical state of p210bcr-abl and the association of p210bcr-abl with Shc and Grb2 in K562 cells
Tyrphostin AG 957 (CAS 140674-76-6) References
Bhatia, R., et al. 1998. Leukemia 12, 1708. Kaur, G., and Sausville, E.A. 1996. Anticancer Drugs 7, 815. Anafi, M., et al. 1992. J. Biol. Chem. 267, 4518.Inhibitor of:
Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin AG 957, 1 mg | sc-204359 | 1 mg | $36.00 | |||
Tyrphostin AG 957, 5 mg | sc-204359A | 5 mg | $133.00 |