Molecular structure of Tyrphostin AG 879, CAS Number: 148741-30-4
Tyrphostin AG 879 (CAS 148741-30-4)
See product citations (4)
Alternate Names:
α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide
Application:
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on TrkA
CAS Number:
148741-30-4
Molecular Weight:
316.50
Molecular Formula:
C18H24N2OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyrphostin AG 879 is a protein tyrosine kinase inhibitor with potent effects on c-trkp140 and TrkA. This product reportedly inhibits inhibited NGF-induced PLC-gamma 1 phosphorylation and phosphatidylinositol-3 kinase activation. Has been shown in lab studies to disrupt Sertoli cell aggregation and stop androgen-induced cell proliferation. AG 879 also displays anti-cancer effects by inhibiting the expression of RAF-1 gene encoding MAP kinase activity necessary for human breast cancer cell proliferation. Shown to inhibit HER-2 expression and reduced tumor sizes in mice leukemia cells.
Tyrphostin AG 879 (CAS 148741-30-4) References
- Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells. | Asslan, R., et al. 1999. Biochem Biophys Res Commun. 260: 699-706. PMID: 10403829
- Interaction between protein tyrosine phosphatase and protein tyrosine kinase is involved in androgen-promoted growth of human prostate cancer cells. | Meng, TC., et al. 2000. Oncogene. 19: 2664-77. PMID: 10851066
- Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity. | Bartsch, O., et al. 2001. Mol Hum Reprod. 7: 799-809. PMID: 11517286
- Novel actions of tyrphostin AG 879: inhibition of RAF-1 and HER-2 expression combined with strong antitumoral effects on breast cancer cells. | Larsson, LI. 2004. Cell Mol Life Sci. 61: 2624-31. PMID: 15526167
- Role of nerve growth factor and its receptors in non-nervous cancer growth: efficacy of a tyrosine kinase inhibitor (AG879) and neutralizing antibodies antityrosine kinase receptor A and antinerve growth factor: an in-vitro and in-vivo study. | Rende, M., et al. 2006. Anticancer Drugs. 17: 929-41. PMID: 16940803
- Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes. | Pagano, E., et al. 2008. J Cell Biochem. 104: 274-85. PMID: 17990290
- Initiation of testicular tubulogenesis is controlled by neurotrophic tyrosine receptor kinases in a three-dimensional Sertoli cell aggregation assay. | Gassei, K., et al. 2008. Reproduction. 136: 459-69. PMID: 18660385
- Effect of tyrphostin AG879 on Kv 4.2 and Kv 4.3 potassium channels. | Yu, H., et al. 2015. Br J Pharmacol. 172: 3370-82. PMID: 25752739
- A cell-based high-throughput screen identifies tyrphostin AG 879 as an inhibitor of animal cell phospholipid and fatty acid biosynthesis. | Zoeller, RA. and Geoghegan-Barek, K. 2019. Biochem Biophys Rep. 18: 100621. PMID: 30899803
- Identification of Small Molecules Affecting the Secretion of Therapeutic Antibodies with the Retention Using Selective Hook (RUSH) System. | Coulet, M., et al. 2023. Cells. 12: PMID: 37371112
Inhibitor of:
γ1-Adaptin, BRI3BP, CCDC91, Clathrin LCB, E74 like ETS transcription factor (ELF), Flk-1, GFRα-4, HNF-3β, Keratocan, LOC100039995, MORN2, Neu, NGF, NGFR p75, OTTMUSG00000011285, OTTMUSG00000011289, SGSM3, Synaptojanin 2, Tyrosine Kinase, UNQ6126, V1RG2, VPS51, YIF1A, and YJEFN3.Activator of:
PDGF-D, PID1, Sgo2, Stat3, and Trk C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin AG 879, 5 mg | sc-3557 | 5 mg | $83.00 | |||
Tyrphostin AG 879, 25 mg | sc-3557A | 25 mg | $328.00 |