Molecular structure of Tyrphostin AG 30, CAS Number: 122520-79-0
AG 30 (CAS 122520-79-0)
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Application:
Tyrphostin AG 30 is a potent PTK inhibitor
CAS Number:
122520-79-0
Molecular Weight:
205.2
Molecular Formula:
C10H7NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Tyrphostin AG 30 is a potent protein tyrosine kinase (PTK) inhibitor specific for EGFR (c-erbB). the compound has been shown to inhibit activation of STAT5 by c-erbB in primary erythroblasts. The compound has been observed to cause induction of the differentiated phenotype in colon cancer cells which is associated with a marked decrease in PTK activity and tyrosine phosphorylation. Unlike other Tyrphostins, Tyrphostin AG 30 was unable to regulate expression of NO-dependent genes in U-937 monocytic cells.
AG 30 (CAS 122520-79-0) References
- Estradiol rapidly activates Akt via the ErbB2 signaling pathway. | Stoica, GE., et al. 2003. Mol Endocrinol. 17: 818-30. PMID: 12554767
- Stimulatory effect of benzylidenemalononitrile tyrphostins on expression of NO-dependent genes in U-937 monocytic cells. | Turpaev, K. and Drapier, JC. 2009. Eur J Pharmacol. 606: 1-8. PMID: 19374863
- Induction of the differentiated phenotype in human colon cancer cell is associated with the attenuation of subcellular tyrosine phosphorylation. | Schwartz, B., et al. 1995. Oncol Res. 7: 277-87. PMID: 8527862
- Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. | Wessely, O., et al. 1997. Cell Growth Differ. 8: 481-93. PMID: 9149900
Inhibitor of:
EGFR, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AG 30, 5 mg | sc-202042 | 5 mg | $33.00 | |||
AG 30, 10 mg | sc-202042A | 10 mg | $80.00 |