Tyrphostin AG 112 (CAS 144978-82-5)

Tyrphostin AG 112 is a compound that functions as a potent and selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It acts by binding to the ATP-binding site of the EGFR, preventing the receptor from phosphorylating downstream signaling molecules and ultimately inhibiting cell proliferation and survival. Tyrphostin Ag 112 targets the tyrosine kinase activity of EGFR, disrupting the signaling cascade involved in cell growth and differentiation. By interfering with the EGFR signaling pathway, Tyrphostin AG 112 has the ability to modulate cellular processes and gene expression, making it useful for studying the role of EGFR in various cellular functions. Its mechanism of action involves blocking the activation of EGFR and downstream signaling pathways, thereby influencing cellular responses to growth factors and other extracellular stimuli. Tyrphostin Ag 112′s ability to selectively inhibit EGFR tyrosine kinase activity may be a useful for investigating the molecular mechanisms underlying cell growth and differentiation.