Molecular structure of Tyrphostin AG 10, CAS Number: 3785-90-8
Tyrphostin AG 10 (CAS 3785-90-8)
Alternate Names:
(4-Hydroxybenzylidene)malononitrile; tyrphostin 8; α-Cyano-(4-hydroxy)cinnamonitrile
Application:
Tyrphostin AG 10 is a transducin GTPase activity inhibitor
CAS Number:
3785-90-8
Purity:
≥98%
Molecular Weight:
170.17
Molecular Formula:
C10H6N2O
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyrphostin AG 10 inhibits the GTPase activity of transducin. Also reported to competitively inhibit calcineurin activity with p-nitrophenyl phosphate as substrate.
Tyrphostin AG 10 (CAS 3785-90-8) References
- Tyrosine phosphorylation is an obligatory event in IL-2 secretion. | Stanley, JB., et al. 1990. J Immunol. 145: 2189-98. PMID: 1697878
- Inhibition of GTP-utilizing enzymes by tyrphostins. | Wolbring, G., et al. 1994. J Biol Chem. 269: 22470-2. PMID: 7915715
- Lipopolysaccharide-stimulated TNF-alpha release from cultured rat Kupffer cells: sequence of intracellular signaling pathways. | Lichtman, SN., et al. 1998. J Leukoc Biol. 64: 368-72. PMID: 9738664
- Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors. | Martin, BL. 1998. Biochem Pharmacol. 56: 483-8. PMID: 9763224
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin AG 10, 5 mg | sc-213132 | 5 mg | $20.00 | |||
Tyrphostin AG 10, 25 mg | sc-213132A | 25 mg | $25.00 | |||
Tyrphostin AG 10, 500 mg | sc-213132B | 500 mg | $166.00 |