Tyrphostin 9 (CAS 10537-47-0)
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Tyrphostin 9, also known by names such as RG-50872, Malonaben, and SF 6847, is a member of the tyrphostin family of protein tyrosine kinase inhibitors. It is utilized in biochemical and cellular research to study the regulation of tyrosine kinase-dependent signaling pathways. By selectively inhibiting specific kinases, Tyrphostin 9 allows researchers to investigate the role of these enzymes in cellular processes such as cell growth, division, differentiation, and the response to external signals. The compound is particularly useful for dissecting signal transduction pathways that contribute to the development of diseases where tyrosine kinase activity is dysregulated. In addition, Tyrphostin 9′s ability to interfere with kinase activity aids in the study of intracellular communication and in the investigation of disease-related signaling.
Tyrphostin 9 (CAS 10537-47-0) References
- Abnormal localisation and hyperclustering of (alpha)(V)(beta)(3) integrins and associated proteins in Src-deficient or tyrphostin A9-treated osteoclasts. | Lakkakorpi, PT., et al. 2001. J Cell Sci. 114: 149-160. PMID: 11112699
- Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid. | Denys, A., et al. 2004. FEBS Lett. 564: 177-82. PMID: 15094063
- Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells. | Bilder, GE., et al. 1991. Am J Physiol. 260: C721-30. PMID: 1850195
- Kinase inhibitors tyrphostin 9 and rottlerin block early steps of rabies virus cycle. | Lama, Z., et al. 2019. Antiviral Res. 168: 51-60. PMID: 31071352
- Development and validation of an LC-MS/MS method for tyrphostin A9. | Meyer, LF. and Shah, DK. 2019. J Pharm Anal. 9: 163-169. PMID: 31297293
- Exploring the interaction between tyrphostin 9 and human serum albumin using biophysical and computational methods. | Kandandapani, S., et al. 2020. J Biomol Struct Dyn. 38: 4134-4142. PMID: 31552810
- Pyk2-dependent phosphorylation of LSR enhances localization of LSR and tricellulin at tricellular tight junctions. | Nakatsu, D., et al. 2019. PLoS One. 14: e0223300. PMID: 31574128
- Dasatinib inhibits peripapillary scleral myofibroblast differentiation. | Chow, A., et al. 2020. Exp Eye Res. 194: 107999. PMID: 32179077
- A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)-mediated multidrug resistance. | Zahra, R., et al. 2020. PLoS One. 15: e0233993. PMID: 32484843
- Out of the blue: Phototropins of the leaf vascular bundle sheath mediate the regulation of leaf hydraulic conductance by blue light. | Grunwald, Y., et al. 2022. Plant Cell. 34: 2328-2342. PMID: 35285491
- Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1. | Yura, Y., et al. 1995. Arch Virol. 140: 1181-94. PMID: 7544112
- Antisense oligonucleotides for PDGF-B and its receptor inhibit mechanical strain-induced fetal lung cell growth. | Liu, M., et al. 1995. Am J Physiol. 269: L178-84. PMID: 7653578
- Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells. | Thyberg, J. 1998. Eur J Cell Biol. 76: 33-42. PMID: 9650781
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin 9, 50 mg | sc-200568 | 50 mg | $106.00 | |||
Tyrphostin 9, 250 mg | sc-200568A | 250 mg | $460.00 |