Molecular structure of Tyrphostin 47, CAS Number: 122520-86-9
Tyrphostin 47 (CAS 122520-86-9)
See product citations (4)
Alternate Names:
RG-50864;Tyrphostin AG-213
Application:
Tyrphostin 47 is a potent inhibitor of EGFR kinase activity
CAS Number:
122520-86-9
Purity:
>97%
Molecular Weight:
220.25
Molecular Formula:
C10H8N2O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tyrphostin 47 is a protein tyrosine kinase inhibitor particularly potent against epidermal growth factor receptor (EGFR) kinase activity. Tyrphostin 47 has been observed to inhibit GTPase activity of transducin and the homologous insulin receptor kinase. It has also been found to also inhibit hyperactive motility of hamster spermatozoa. Tyrphostin 47 interferes with the proximal EGFR signaling pathway, causes G1-S transition arrest, and induces apoptosis in the human MCF-7 breast cancer cell line. In vero cell cultures, this product induced cell death and p38 MAPK phosphorylation.
Tyrphostin 47 (CAS 122520-86-9) References
- Effects of inhibitors of the tyrosine kinase signaling cascade on an in vitro model of allergic airways. | Wong, WS., et al. 1999. Asian Pac J Allergy Immunol. 17: 229-37. PMID: 10697263
- Effects of receptor tyrosine kinase inhibitor A47 on estrogen and growth factor-dependent breast cancer cell proliferation and apoptosis in vitro. | Turbov, JM., et al. 2002. J Surg Oncol. 79: 17-29. PMID: 11754373
- Mechanisms underlying pervanadate-induced contraction of rat cremaster muscle arterioles. | Murphy, TV., et al. 2002. Eur J Pharmacol. 442: 107-14. PMID: 12020688
- Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa. | Mariappa, D., et al. 2006. Mol Reprod Dev. 73: 215-25. PMID: 16220544
- Inhibitory effect of tyrphostin 47 on Shiga toxin-induced cell death. | Ikeda, M., et al. 2006. Eur J Pharmacol. 546: 36-9. PMID: 16919262
- TPX2 in malignantly transformed human bronchial epithelial cells by anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. | Zhang, L., et al. 2008. Toxicology. 252: 49-55. PMID: 18723071
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. | Erfinanda, L., et al. 2022. Sci Transl Med. 14: eabg8577. PMID: 36475904
- Inhibitory effect of tyrphostin on the replication of herpes simplex virus type 1. | Yura, Y., et al. 1995. Arch Virol. 140: 1181-94. PMID: 7544112
- Tyrphostin 47 nonenzymatically decarboxylates [1-14C]-pyruvate. | Kiechle, FL., et al. 1994. Ann Clin Lab Sci. 24: 422-30. PMID: 7818237
- Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers. | Sears, CL., et al. 1995. Am J Physiol. 269: G874-82. PMID: 8572219
- Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth-muscle cell proliferation in a rat carotid balloon-injury model. | Gottsauner-Wolf, M., et al. 1997. Am Heart J. 133: 329-34. PMID: 9060802
- Mechanism of action of a tyrphostin, 3,4-dihydroxy-alpha-cyanothiocinnamamide, in breast cancer cell growth inhibition involves the suppression of cyclin B1 and the functional activity of cyclin B1/p34cdc2 complex. | Faaland, CA., et al. 1997. Breast Cancer Res Treat. 44: 47-56. PMID: 9164677
- Role of tyrosine kinase in serotonin-induced constriction of the basilar artery in vivo. | Kitazono, T., et al. 1998. Stroke. 29: 494-7; discussion 498. PMID: 9472895
Inhibitor of:
EGFR, and Tyrosine Kinase.Activator of:
GAK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin 47, 5 mg | sc-200543 | 5 mg | $79.00 | |||
Tyrphostin 47, 25 mg | sc-200543A | 25 mg | $315.00 |