Tyro3 Antibody (1444CT895.86.31): sc-517370
- Tyro3 Antibody (1444CT895.86.31) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to Tyro3 of human origin
- recommended for detection of Tyro3 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Tyro3 Antibody (1444CT895.86.31). This work is in progress.
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Tyro3 Antibody (1444CT895.86.31) is a mouse monoclonal IgG1 antibody that detects Tyro3 in mouse, rat, and human samples through western blotting (WB). Tyro3 is a member of the Axl/UFO subfamily of receptor tyrosine kinases, which play a crucial role in various biological processes, including spermatogenesis, immunoregulation, and phagocytosis. Tyro3 is primarily located on the cell membrane, where Tyro3 functions as a transmembrane signaling molecule. Upon binding to ligands, such as Protein S and Gas6, Tyro3 undergoes dimerization, activating intrinsic tyrosine kinase activity, which subsequently triggers downstream signaling pathways essential for cellular responses. Tyro3 expression is notably abundant in tissues such as the brain, testis, and lymphatic and vascular systems, highlighting Tyro3′s importance in both the central nervous system and immune response. Additionally, Tyro3 undergoes post-translational modifications, including tyrosine phosphorylation and glycosylation, which can influence activity and interactions with other proteins. Anti-Tyro3 antibody (1444CT895.86.31) is an invaluable tool for researchers studying the functional dynamics of this receptor and its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tyro3 Antibody (1444CT895.86.31) References:
- A genomic screen identifies TYRO3 as a MITF regulator in melanoma. | Zhu, S., et al. 2009. Proc Natl Acad Sci U S A. 106: 17025-30. PMID: 19805117
- Involvement of the Tyro3 receptor and its intracellular partner Fyn signaling in Schwann cell myelination. | Miyamoto, Y., et al. 2015. Mol Biol Cell. 26: 3489-503. PMID: 26224309
- Inhibition of TYRO3/Akt signaling participates in hypoxic injury in hippocampal neurons. | Zhu, YZ., et al. 2016. Neural Regen Res. 11: 752-7. PMID: 27335558
- The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation. | Kim, DY., et al. 2017. Dis Model Mech. 10: 581-595. PMID: 28093506
- The TAM receptor Tyro3 regulates myelination in the central nervous system. | Akkermann, R., et al. 2017. Glia. 65: 581-591. PMID: 28145605
- Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology. | Fujita, K., et al. 2018. Nat Commun. 9: 433. PMID: 29382817
- Galectin-3 Stimulates Tyro3 Receptor Tyrosine Kinase and Erk Signalling, Cell Survival and Migration in Human Cancer Cells. | Al Kafri, N. and Hafizi, S. 2020. Biomolecules. 10: PMID: 32664510
- Phosphoproteomic Analysis Identifies TYRO3 as a Mediator of Sunitinib Resistance in Metastatic Thymomas. | Küffer, S., et al. 2022. Cancers (Basel). 14: PMID: 36230684
- TYRO3 and EPHA2 Expression Are Dysregulated in Breast Cancer. | de Aguiar, ACF., et al. 2024. Cell Biochem Funct. 42: e4128. PMID: 39327735
- Distinct TYRO3 and PROS1 expression levels contribute to preeclampsia pathogenesis. | Kirimlioglu, E., et al. 2025. Histochem Cell Biol. 163: 29. PMID: 39878883
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyro3 Antibody (1444CT895.86.31) | sc-517370 | 100 µg/ml | $322.00 |