Tyrene CR4 (CAS 1110670-40-0)
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Tyrene CR4 is a cell-permeable, reversible, and substrate competitive hydroxystryrylacrylonitrile tyrosine kinase inhibitor that show anti-tumor properties. Tyrene CR4 potently inhibits JAK2 and Bcr-Abl (the fusion protein of Bcr and c-Abl) (IC50 ~100-600 nM and 500-700 nM, respectively) by targeting their kinase activities. Tyrene CR4 displays excellent selectivity over other tyrosine kinases, Btk, Lck, Lyn, Src, Syk and ZAP-70 (IC50 >5 muM). Tyrene CR4 may act to preferentially induce apoptosis in acute lymphoblastic (ALL) and myeloid leukemia cells (AML), while exhibiting little deleterious effect towards normal bone marrow cell differentiation and proliferation. Tyrene CR4 has also been reported to be more potent than AG 490 (sc-202046) in inducing ALL cells growth arrest (IC50 ~ 120 nM vs. 5-25 muM).
Tyrene CR4 (CAS 1110670-40-0) References
- Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. | Helmer, RA., et al. 2010. Mol Cell Endocrinol. 325: 143-9. PMID: 20562009
- Prolactin induces Jak2 phosphorylation of RUSHY195. | Helmer, RA., et al. 2011. Mol Cell Endocrinol. 338: 79-83. PMID: 21457752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrene CR4, 5 mg | sc-296677 | 5 mg | $101.00 | |||
Tyrene CR4, 50 mg | sc-296677A | 50 mg | $754.00 |