Tylvalosin (CAS 63409-12-1)
Alternate Names:
Tylvalosin is also known as Acetylisovaleryltylosin.
Application:
Tylvalosin is an enzyme inhibitor and macrolide antibiotic drug, meant to treat porcine respiratory diseases.
CAS Number:
63409-12-1
Purity:
≥90%
Molecular Weight:
1042.25
Molecular Formula:
C53H87NO19
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tylvalosin is a macrolide antibiotic utilized in non-clinical research applications to explore its impact on various bacterial populations, particularly those affecting animals. The compound′s mode of action, inhibiting bacterial protein synthesis, makes it a point of interest for studies on the mechanisms of bacterial growth inhibition. It is often used in investigations of the efficacy of feed additives on animal bacterial flora and the resultant effects on gut health. Additionally, research on tylvalosin includes studies on the environmental impact of antibiotics used in agriculture, such as their presence in waste streams and potential effects on non-target organisms. Researchers also analyze the pharmacokinetics and pharmacodynamics of tylvalosin in different environments to understand its behavior and stability under various conditions.
Tylvalosin (CAS 63409-12-1) References
- Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. | Guedes, RM., et al. 2009. Vet Rec. 165: 342-5. PMID: 19767637
- Impact of the type of catheter on the absorption of tylvalosin (acetylvaleryltylosin) administered orally to broiler chickens. | Cerdá, RO., et al. 2010. J Vet Pharmacol Ther. 33: 202-3. PMID: 20444046
- Mycoplasma gallisepticum in pheasants and the efficacy of tylvalosin to treat the disease. | Forrester, CA., et al. 2011. Avian Pathol. 40: 581-6. PMID: 22107092
- Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. | Zhao, Z., et al. 2014. Biochem Pharmacol. 90: 73-87. PMID: 24792436
- In vitro activity of tylvalosin against Spanish field strains of Mycoplasma hyopneumoniae. | Tavío, MM., et al. 2014. Vet Rec. 175: 539. PMID: 25185108
- Use of tylvalosin in the control of porcine enzootic pneumonia. | Pallarés, FJ., et al. 2015. Vet Rec Open. 2: e000079. PMID: 26392896
- Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. | El-Ela, FI., et al. 2016. Res Vet Sci. 108: 25-32. PMID: 27663366
- Determination of the Mutant Selection Window and Evaluation of the Killing of Mycoplasma gallisepticum by Danofloxacin, Doxycycline, Tilmicosin, Tylvalosin and Valnemulin. | Zhang, N., et al. 2017. PLoS One. 12: e0169134. PMID: 28052123
- Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1. | Moges, R., et al. 2018. Front Vet Sci. 5: 57. PMID: 29696149
- Pharmacokinetics of Tylvalosin in Broiler Turkeys (Meleagris Gallopavo) After Single Intravenous and Oral Administration. | Elbadawy, M., et al. 2019. Front Vet Sci. 6: 355. PMID: 31681811
- Evaluation of the clinical efficacy of a water soluble formulation of tylvalosin in the control of enzootic pneumonia associated with Mycoplasma hyopneumoniae and Pasteurella multocida in pigs. | Lopez Rodriguez, A., et al. 2020. Porcine Health Manag. 6: 39. PMID: 33292620
- Tylvalosin demonstrates anti-parasitic activity and protects mice from acute toxoplasmosis. | Yuan, W., et al. 2022. Life Sci. 294: 120373. PMID: 35123999
- Quantification and Determination of Stability of Tylvalosin in Pig Plasma by Ultra-High Liquid Chromatography with Ultraviolet Detection. | Hernandis, V., et al. 2022. Animals (Basel). 12: PMID: 35681849
- Effects of a water-soluble formulation of tylvalosin on disease caused by porcine reproductive and respiratory syndrome virus alone in sows or in combination with Mycoplasma hyopneumoniae in piglets. | Rodriguez, AL., et al. 2023. BMC Vet Res. 19: 31. PMID: 36726139
- Tylvalosin Induces Apoptosis Of Porcine Neutrophils And Macrophages, Efferocytosis By Porcine Macrophages And Modulation Of Lipid Mediators Of Inflammation In Vitro: A New Class Of Anti-Microbial With Anti-Inflammatory And Pro-Resolution Properties? | Ruth Moges, et al. 2017. The FASEB Journal. 31: 469.7-469.7.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tylvalosin, 1 mg | sc-473950 | 1 mg | $449.00 |