TXNL6 Antibody (3-RE25): sc-135593

TXNL6 Antibody (3-RE25) is a mouse monoclonal IgG2b kappa light chain antibody that detects TXNL6 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TXNL6 (3-RE25) antibody is available as a non-conjugated format. TXNL6, also known as thioredoxin-like 6, nucleoredoxin-like 1, or rod-derived cone viability factor, is a 212 amino acid protein located in the nuclear outer membrane and belongs to the nucleoredoxin family. TXNL6 contains a thioredoxin domain, which is crucial for cellular redox regulation. TXNL6 protects cone photoreceptor cells from photooxidative stress-induced apoptosis, potentially in collaboration with NFκB. Mutations in TXNL6 have been linked to age-related declines in cone and rod function, contributing to rod-cone dystrophies such as retinitis pigmentosa, a hereditary retinal disease that can lead to blindness. Given TXNL6′s protective role in retinal health, TXNL6 is considered a promising target for developing therapeutic strategies aimed at treating human retinal neurodegenerative diseases. TXNL6 is located on human chromosome 19, highlighting significance in genetic studies related to vision disorders.

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TXNL6 Antibody (3-RE25) References:

1. Identification and characterization of rod-derived cone viability factor.  |  Léveillard, T., et al. 2004. Nat Genet. 36: 755-9. PMID: 15220920
2. [Neuroprotection of photoreceptor cells in rod-cone dystrophies: from cell therapy to cell signalling].  |  Sahel, JA., et al. 2005. C R Biol. 328: 163-8. PMID: 15771002
3. Disease-associated variants of the rod-derived cone viability factor (RdCVF) in Leber congenital amaurosis. Rod-derived cone viability variants in LCA.  |  Hanein, S., et al. 2006. Adv Exp Med Biol. 572: 9-14. PMID: 17249548
4. Rod-derived Cone Viability Factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential.  |  Chalmel, F., et al. 2007. BMC Mol Biol. 8: 74. PMID: 17764561
5. Thioredoxin-like 6 protects retinal cell line from photooxidative damage by upregulating NF-kappaB activity.  |  Wang, XW., et al. 2008. Free Radic Biol Med. 45: 336-44. PMID: 18474255
6. Functional cone rescue by RdCVF protein in a dominant model of retinitis pigmentosa.  |  Yang, Y., et al. 2009. Mol Ther. 17: 787-95. PMID: 19277021
7. The thioredoxin-like protein rod-derived cone viability factor (RdCVFL) interacts with TAU and inhibits its phosphorylation in the retina.  |  Fridlich, R., et al. 2009. Mol Cell Proteomics. 8: 1206-18. PMID: 19279044
8. The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.  |  Reichman, S., et al. 2010. Hum Mol Genet. 19: 250-61. PMID: 19843539
9. The disruption of the rod-derived cone viability gene leads to photoreceptor dysfunction and susceptibility to oxidative stress.  |  Cronin, T., et al. 2010. Cell Death Differ. 17: 1199-210. PMID: 20139892

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TXNL6 Antibody (3-RE25) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TXNL6 Antibody (3-RE25) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TXNL6 Antibody (3-RE25) Specifications

Alternate Product Name: TXNL6

Product Clone Name: 3-RE25

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 81-191

Epitope Target: TXNL6

Epitope Species: human

Product Reactivity/Detection: TXNL6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TXNL6 Antibody (3-RE25): N/A