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TXB2 (Thromboxane B2) (CAS 54397-85-2)

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Application:
TXB2 (Thromboxane B2) is a stable metabolite of thromboxane B2
CAS Number:
54397-85-2
Purity:
≥99%
Molecular Weight:
370.50
Molecular Formula:
C20H34O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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TXB2 (Thromboxane B2) is a metabolite of Thromboxane A2 and is widely studied in biochemistry and physiology research. It is involved in the investigation of blood platelet aggregation mechanisms and the study of vascular constriction processes. As a stable non-active metabolite, Thromboxane B2 serves as an important marker in studies measuring the production of Thromboxane A2 within various biological systems. In cardiovascular research, the levels of Thromboxane B2 are analyzed to understand its role in blood flow and clot formation. Moreover, researchers utilize Thromboxane B2 in experimental models to monitor the efficacy of different interventions that affect the Thromboxane pathway, providing insight into the regulation of vascular and platelet functions.


TXB2 (Thromboxane B2) (CAS 54397-85-2) References

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  2. Setting up a 2D-LC/MS/MS method for the rapid quantitation of the prostanoid metabolites 6-oxo-PGF(1alpha) and TXB2 as markers for hemostasis assessment.  |  Casetta, B., et al. 2009. J Mass Spectrom. 44: 346-52. PMID: 18942642
  3. Thromboxane in cardiovascular disease.  |  Sinzinger, H., et al. 1990. Eicosanoids. 3: 59-64. PMID: 2328134
  4. Thromboxane A2 in cardiovascular and renal disorders: is there a defined role for thromboxane receptor antagonists or thromboxane synthase inhibitors?  |  Smith, EF. 1989. Eicosanoids. 2: 199-212. PMID: 2534279
  5. Age-related increase of thromboxane B2 and risk of cardiovascular disease in atrial fibrillation.  |  Pastori, D., et al. 2016. Oncotarget. 7: 39143-39147. PMID: 27270651
  6. Circulating and urinary thromboxane B2 metabolites in the rabbit: 11-dehydro-thromboxane B2 as parameter of thromboxane production.  |  Westlund, P., et al. 1986. Prostaglandins. 31: 413-43. PMID: 3520685
  7. Tandem mass spectrometric determination of 11-dehydrothromboxane B2, an index metabolite of thromboxane B2 in plasma and urine.  |  Schweer, H., et al. 1987. Anal Biochem. 164: 156-63. PMID: 3674365
  8. Effect of experimental cardiopulmonary bypass on systemic and transcardiac thromboxane B2 levels.  |  Kobinia, GS., et al. 1986. J Thorac Cardiovasc Surg. 91: 852-7. PMID: 3754915
  9. A solid-phase enzyme immunoassay of thromboxane B2.  |  Shono, F., et al. 1985. J Biochem. 98: 1069-77. PMID: 3935648
  10. Metabolism of thromboxane B2 in man. Identification of twenty urinary metabolites.  |  Roberts, LJ., et al. 1981. J Biol Chem. 256: 8384-93. PMID: 7263660
  11. Thromboxane B2 transformed from arachidonic acid in carrageenin-induced granuloma.  |  Chang, WC., et al. 1977. Prostaglandins. 13: 17-24. PMID: 841103
  12. The effect of thromboxane A2 receptor antagonism on amphotericin B-induced renal vasoconstriction in the rat.  |  Hardie, WD., et al. 1993. Prostaglandins. 45: 47-56. PMID: 8424133
  13. Metabolism of thromboxane B2 in man. Identification of the major urinary metabolite.  |  Roberts, LJ., et al. 1977. J Biol Chem. 252: 7415-7. PMID: 914816

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

TXB2 (Thromboxane B2), 1 mg

sc-201452
1 mg
$90.00

TXB2 (Thromboxane B2), 5 mg

sc-201452A
5 mg
$617.00

TXB2 (Thromboxane B2), 10 mg

sc-201452B
10 mg
$903.00

TXB2 (Thromboxane B2), 50 mg

sc-201452C
50 mg
$4391.00

TXB2 (Thromboxane B2), 100 mg

sc-201452D
100 mg
$8512.00