twist Antibody (Twist2C1a): sc-81417

twist Antibody (Twist2C1a) is a mouse monoclonal IgG1 kappa light chain antibody that detects twist protein in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). anti-twist antibody (Twist2C1a) is available as a non-conjugated format. twist protein, a member of the basic helix-loop-helix (bHLH) transcription factor family, plays a crucial role in regulating mesodermal differentiation and myogenesis, making twist essential for proper muscle development. twist protein is primarily expressed in the epithelial somite, where twist acts as a negative regulator of myogenic regulatory factors by dimerizing with E proteins, thereby inhibiting their function. This regulatory mechanism is vital for the temporal and spatial formation of myotomes, as twist ensures that muscle tissue develops correctly from the embryonic mesoderm. twist interaction with other proteins in the myogenic determination family highlights twist importance in muscle cell lineage specification and differentiation, underscoring twist significance in developmental biology and potential implications in muscle-related disorders.

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twist Antibody (Twist2C1a) References:

1. Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location.  |  El Ghouzzi, V., et al. 2000. Hum Mol Genet. 9: 813-9. PMID: 10749989
2. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target.  |  Kwok, WK., et al. 2005. Cancer Res. 65: 5153-62. PMID: 15958559
3. Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer.  |  Yuen, HF., et al. 2007. Histopathology. 50: 648-58. PMID: 17394502
4. Retinoblastoma cell-derived Twist protein promotes regulatory T cell development.  |  Zhang, R., et al. 2021. Cancer Immunol Immunother. 70: 1037-1048. PMID: 33108472
5. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.  |  Lee, JE., et al. 1995. Science. 268: 836-44. PMID: 7754368
6. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.  |  Naya, FJ., et al. 1995. Genes Dev. 9: 1009-19. PMID: 7774807
7. Determinants of helix-loop-helix dimerization affinity. Random mutational analysis of SCL/tal.  |  Goldfarb, AN., et al. 1996. J Biol Chem. 271: 2683-8. PMID: 8576241
8. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist.  |  Spicer, DB., et al. 1996. Science. 272: 1476-80. PMID: 8633239
9. twist: a myogenic switch in Drosophila.  |  Baylies, MK. and Bate, M. 1996. Science. 272: 1481-4. PMID: 8633240
10. Id2 expression increases with differentiation of human myeloid cells.  |  Ishiguro, A., et al. 1996. Blood. 87: 5225-31. PMID: 8652837
11. Substitution of basic amino acids in the basic region stabilizes DNA binding by E12 homodimers.  |  Vitola, SJ., et al. 1996. Nucleic Acids Res. 24: 1921-7. PMID: 8657575
12. Twist protein in mouse embryogenesis.  |  Gitelman, I. 1997. Dev Biol. 189: 205-14. PMID: 9299114

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-twist Antibody (Twist2C1a) has 251 citations in a variety of scientific publications.

Primary antibodies like Anti-twist Antibody (Twist2C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

twist Antibody (Twist2C1a) Specifications

Alternate Product Name: twist

Product Clone Name: Twist2C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: twist

Epitope Species: human

Product Reactivity/Detection: twist

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 251 citations in various scientific publications

Available Conjugates/Forms for twist Antibody (Twist2C1a): N/A