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Tween 85 (CAS 9005-70-3)

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Alternate Names:
Polyoxyethylene Sorbitan Trioleate
CAS Number:
9005-70-3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tween 85, known chemically as polyoxyethylene sorbitan trioleate, is a versatile nonionic surfactant renowned for its emulsifying properties, particularly in the stabilization of oil-water mixtures. This compound, derived from the esterification of sorbitan with oleic acid and subsequent ethoxylation, possesses a unique amphiphilic structure that enables it to reduce surface and interfacial tensions effectively. Its mechanism centers around the surfactant′s ability to orient its hydrophilic (polyethylene oxide chains) and lipophilic (fatty acid tails) segments at the interface of immiscible phases, thereby facilitating the formation and stabilization of emulsions. In research applications, Tween 85 is extensively used not only to enhance the solubility of hydrophobic substances in aqueous environments but also as a critical component in the formulation of nanoparticle systems, where it acts as a stabilizer to prevent particle aggregation. Additionally, its mild nature and low toxicity make it ideal for investigations in biochemical processes and drug delivery systems, where it supports the development of biocompatible materials that are essential for advancing therapeutic practices. These attributes underscore Tween 85′s significant role in promoting more efficient and effective scientific studies and industrial processes.


Tween 85 (CAS 9005-70-3) References

  1. Biodegradation of pesticides in nonionic water-in-oil microemulsions of tween 85: Relationship between micelle structure and activity.  |  Komives, CF., et al. 1994. Biotechnol Bioeng. 43: 946-59. PMID: 18615442
  2. Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo.  |  Liu, H., et al. 2009. J Pharm Sci. 98: 1167-76. PMID: 18729203
  3. Low molecular weight polyethylenimine-graft-Tween 85 for effective gene delivery: synthesis and in vitro characteristics.  |  Xiao, J., et al. 2012. Bioconjug Chem. 23: 222-31. PMID: 22168476
  4. Effective delivery of p65 shRNA by optimized Tween 85-polyethyleneimine conjugate for inhibition of tumor growth and lymphatic metastasis.  |  Xiao, J., et al. 2014. Acta Biomater. 10: 2674-83. PMID: 24525035
  5. Hydrogels based on poly(methyl vinyl ether-co-maleic acid) and Tween 85 for sustained delivery of hydrophobic drugs.  |  Larrañeta, E., et al. 2018. Int J Pharm. 538: 147-158. PMID: 29353081
  6. Lubrication and Dynamically Controlled Drug Release Properties of Tween 85/Tween 80/H2O Lamellar Liquid Crystals.  |  Lu, X., et al. 2021. Langmuir. 37: 7067-7077. PMID: 34080864
  7. Acrylamide as cosurfactant and hydrotrope in the pseudoternary Span 80-Tween 85/isopar M/water emulsion/microemulsion forming system  |  Jian-Hang Zhu a b, Feng Shao b, Yu-Hang Zhan b, Xi-Luan Yan a b, Bao Zhang c. 2006. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 290: 19-24.
  8. Inhibition by tween-85 of the corrosion of cold rolled steel in 1.0 M hydrochloric acid solution  |  **ang-Hong Li, Shu-Duan Deng, Hui Fu & Guan-Nan Mu. 2009. Journal of Applied Electrochemistry. 39: 1125–1135.
  9. Thermodynamic investigation of binary surfactant mixtures of Tween 85/Triton X100 and 85/Triton X165 in water solution – Binary mixed micelles formation  |  Mihalj Poša, Dejan Ćirin, Ivana Vapa. 2017. The Journal of Chemical Thermodynamics. 106: 113-122.
  10. Tween 85 Oil-in-Water Nanoemulsions with Incorporated Chlorhexidine Base  |  N. M. Zadymova, M. Tao & M. V. Poteshnova. 2018. Colloid Journal. 80.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tween 85, 5 g

sc-296674
5 g
$40.00

Tween 85, 25 g

sc-296674A
25 g
$68.00