Date published: 2026-4-5

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Tween 65 (CAS 9005-71-4)

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Alternate Names:
Polyoxyethylenesorbitan Tristearate
CAS Number:
9005-71-4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tween 65 is a non-ionic surfactant that functions as an emulsifier and stabilizer. It acts by reducing the surface tension between two immiscible phases allowing them to mix uniformly. Tween 65′s mechanism of action involves forming a protective layer around the dispersed phase, preventing coalescence and maintaining the stability of the emulsion. Tween 65 achieves this by adsorbing at the interface between the two phases, creating a barrier that inhibits the merging of droplets. This surfactant′s functional role includes enhancing the solubility of hydrophobic substances in aqueous solutions, facilitating the dispersion of particles, and improving the consistency of mixtures.


Tween 65 (CAS 9005-71-4) References

  1. Optimization of mono and diacylglycerols production from enzymatic glycerolysis in solvent-free systems.  |  Valério, A., et al. 2010. Bioprocess Biosyst Eng. 33: 805-12. PMID: 20091052
  2. Emulsification using highly hydrophilic surfactants improves the absorption of orally administered coenzyme Q10.  |  Sato, Y., et al. 2013. Biol Pharm Bull. 36: 2012-7. PMID: 24292061
  3. Nonionic surfactant-based vesicular system for transdermal drug delivery.  |  Ghanbarzadeh, S., et al. 2015. Drug Deliv. 22: 1071-1077. PMID: 24400680
  4. Optimization of diacylglycerol production by glycerolysis of fish oil catalyzed by Lipozyme TL IM with Tween 65.  |  Monte Blanco, SF., et al. 2015. Bioprocess Biosyst Eng. 38: 2379-88. PMID: 26391508
  5. Formulation of chitosan coated nanoliposomes for the oral delivery of colistin sulfate: in vitro characterization, 99mTc-radiolabeling and in vivo biodistribution studies.  |  Aboumanei, MH., et al. 2021. Drug Dev Ind Pharm. 47: 626-635. PMID: 33834934

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tween 65, 250 g

sc-471373
250 g
$62.00

Tween 65, 1 kg

sc-471373A
1 kg
$183.00