TUG 891 (CAS 1374516-07-0)
CAS Number:
1374516-07-0
Molecular Weight:
364.41
Molecular Formula:
C23H21FO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
TUG 891, also known as 3-(4-{[5-Fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid (FPPA) ,studies have utilized the compound to scrutinize its impact on molecular signaling, gene activity, and enzymatic functions. While the precise mode of action of TUG 891 remains to be fully elucidated, it is postulated that its biological effects are initiated by its binding to specific cellular receptors. This interaction is thought to set off a series of cellular events, resulting in the observed outcomes. Additionally, TUG 891′s ability to regulate certain enzyme activities is also considered a key aspect of its mode of action.
TUG 891 (CAS 1374516-07-0) References
- The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. | Hudson, BD., et al. 2013. Mol Pharmacol. 84: 710-25. PMID: 23979972
- The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat. | Schilperoort, M., et al. 2018. EMBO Mol Med. 10: PMID: 29343498
- Docosahexaenoic acid and TUG-891 activate free fatty acid-4 receptor in bovine neutrophils. | Olmo, I., et al. 2019. Vet Immunol Immunopathol. 209: 53-60. PMID: 30885306
- Characterization of the metabolites of TUG-891 in rat, dog, and human hepatocytes using ultra-high-performance liquid chromatography tandem mass spectrometry and nuclear magnetic resonance spectroscopy. | Shi, Q., et al. 2020. Rapid Commun Mass Spectrom. 34: e8766. PMID: 32108961
- Elucidation of the roles of brown and brite fat genes: GPR120 is a modulator of brown adipose tissue function. | Christian, M. 2020. Exp Physiol. 105: 1201-1205. PMID: 32144819
- The GPR120 Agonist TUG-891 Inhibits the Motility and Phagocytosis of Mouse Alveolar Macrophages. | Su, XL., et al. 2020. Biomed Res Int. 2020: 1706168. PMID: 32149083
- Simultaneous determination of TUG-891 and its metabolites in rat plasma using LC-HRMS with application to preclinical pharmacokinetic study. | Yi, J., et al. 2020. Biomed Chromatogr. 34: e4870. PMID: 32346871
- GPR120 Regulates Pancreatic Polypeptide Secretion From Male Mouse Islets via PLC-Mediated Calcium Mobilization. | Zhao, YF., et al. 2020. Endocrinology. 161: PMID: 32877513
- The Anti-Atherosclerotic Action of FFAR4 Agonist TUG-891 in ApoE-Knockout Mice Is Associated with Increased Macrophage Polarization towards M2 Phenotype. | Kiepura, A., et al. 2021. Int J Mol Sci. 22: PMID: 34575934
- GPR120 Inhibits RANKL-Induced Osteoclast Formation and Resorption by Attenuating Reactive Oxygen Species Production in RAW264.7 Murine Macrophages. | Sithole, C., et al. 2021. Int J Mol Sci. 22: PMID: 34638884
- FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury. | Yang, L., et al. 2022. Signal Transduct Target Ther. 7: 384. PMID: 36450712
- The Influence of the FFAR4 Agonist TUG-891 on Liver Steatosis in ApoE-Knockout Mice. | Kiepura, A., et al. 2023. Cardiovasc Drugs Ther.. PMID: 36705799
- Effects of TUG-891, a potent GPR120 agonist, on the physical and oral lipid- coating properties, and secretion of saliva. | Kitajima, S., et al. 2023. Physiol Behav. 265: 114160. PMID: 36934827
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TUG 891, 10 mg | sc-473987 | 10 mg | $331.00 |