Tubulin Polymerization Inhibitor CAS: 564468-51-5
MF: C22H16O3
MW: 328.37
An antimicrotubule agent.

Tubulin Polymerization Inhibitor (CAS 564468-51-5)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 102ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An antimicrotubule agent
CAS Number: 564468-51-5
Molecular Weight: 328.37
Molecular Formula: C22H16O3
* Refer to Certificate of Analysis for lot specific data (including water content).

Tubulin Polymerization Inhibitor is a low molecular weight, cell-permeable, benzylidene-anthracenone antimicrotubule agent that exhibits potent antitumor activity (IC50 = 20 and 50 nM in inhibiting Tumor cell growth in K562 and SKOV3 cells, respectively) comparable to other commonly used antitumor agents. Unlike Paclitaxel , Vinblastine , or Vincristine , it does not function as a substrate for Pgp-170 and exhibits cytotoxic effects towards tumor cell lines with various MDR resistance phenotypes. It is shown to interact with Tubulin at the Colchicine, but not the Vinblastine, binding site.


1. Prinz, H., et al. 2003. J. Med. Chem. 46: 3382-3394. PMID: 19220018

Physical State :
Solubility :
Soluble in DMSO (1 mg/ml).
Storage :
Store at 4° C
Density :
~1.30 g/cm3 (Predicted)
Refractive Index :
n20D ~1.70 (Predicted)
IC50 :
RXF 944: IC50 = 10 nM (human); MCF7: IC50 = 10 nM (human); Human breast 401NL tumor cell line: IC50 = 10 nM (human); NCI-H460: IC50 = 10 nM (human)
pK Values :
pKa: 9.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
MDL Number :

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 138ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.