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Tubermycin B (CAS 2538-68-3)

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Alternate Names:
1-phenazinecarboxylic acid
Application:
Tubermycin B is an antibacterial compound which aids in the biocontrol of plant diseases
CAS Number:
2538-68-3
Purity:
≥95%
Molecular Weight:
224.21
Molecular Formula:
C13H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tubermycin B is a highly versatile organic compound that finds extensive use. Exhibiting a colorless solid form, Tubermycin B demonstrates solubility in both water and organic solvents. Its significance lies in its role as a intermediate in the synthesis of numerous agrochemicals. Tubermycin B serves as a fundamental building block for synthesizing various organic compounds. Tubermycin B has also played a role in examining plant physiology, in studies focusing on photosynthesis and respiration. Tubermycin B has been integral to the exploration of cell signaling pathways, shedding light on its involvement in regulating gene expression. Although the complete mechanism of action of Tubermycin B remains elusive, it is postulated that Tubermycin B binds to the active site of enzymes, consequently inhibiting their activity. This inhibition is believed to stem from the formation of a hydrogen bond between Tubermycin B and the enzyme′s active site. Tubermycin B is thought to interact with other cellular molecules, including proteins and lipids.


Tubermycin B (CAS 2538-68-3) References

  1. Fatty acids enhanced tubermycin production by Pseudomonas strain 2HS.  |  Keudell, KC., et al. 2000. Microbios. 102: 27-38. PMID: 10817518
  2. Endophenazines A-D, new phenazine antibiotics from the arthropod associated endosymbiont Streptomyces anulatus. I. Taxonomy, fermentation, isolation and biological activities.  |  Gebhardt, K., et al. 2002. J Antibiot (Tokyo). 55: 794-800. PMID: 12458768
  3. Metabolites of microorganisms. 247. Phenazines from Streptomyces antibioticus, strain Tü 2706.  |  Geiger, A., et al. 1988. J Antibiot (Tokyo). 41: 1542-51. PMID: 3058669
  4. Strepoxazine A, a new cytotoxic phenoxazin from the marine sponge-derived bacterium Streptomyces sp. SBT345  |  Cheng Cheng a, Eman M. Othman b f, Agnes Fekete c, Markus Krischke c, Helga Stopper b, RuAngelie Edrada-Ebel d, Martin J. Mueller c, Ute Hentschel e, Usama Ramadan Abdelmohsen a g. 2016. Tetrahedron Letters. 57: 4196-4199.
  5. Marine Brevibacterium aureum Extract and Its Constituent's Saphenic Acid a Derivative of 1-phenazinecarboxylic Acid (Tubermycin B), Initiate Apoptosis via Inhibition of NF-κB and MAPK Expression  |  Susan A Ibrahim, Nadal Al saryi, Helal F Hetta & Abdulwahab Ali Abuderman. 2018. Toxicology and Environmental Health Sciences. 10: 321–329.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tubermycin B, 1 mg

sc-391639
1 mg
$116.00