Tuberculostearic Acid (CAS 542-47-2)
Alternate Names:
10-Methyloctadecanoic acid
Application:
Fatty acid derived from Actinomycetales bacteria.
CAS Number:
542-47-2
Molecular Weight:
298.50
Molecular Formula:
C19H38O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Tuberculostearic acid, a unique long-chain fatty acid, is exclusively present in the cell walls of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. Moreover, researchers have explored the utility of tuberculostearic acid as a biomarker for tuberculosis, capitalizing on its exclusive presence in Mycobacterium tuberculosis cell walls. It is believed to contribute to the structural integrity of these bacterial cell walls, providing stability and protection against the host immune system.
Tuberculostearic Acid (CAS 542-47-2) References
- Demonstration of tuberculostearic acid in sputum from patients with pulmonary tuberculosis by selected ion monitoring. | Odham, G., et al. 1979. J Clin Invest. 63: 813-9. PMID: 109465
- Apoptosis modulation by mycolic acid, tuberculostearic acid and trehalose 6,6'-dimycolate. | Nuzzo, I., et al. 2002. J Infect. 44: 229-35. PMID: 12099729
- Bronchoscopy and tuberculostearic acid assay in the diagnosis of sputum smear-negative pulmonary tuberculosis: a prospective study with the addition of transbronchial biopsy. | Chan, CH., et al. 1992. Q J Med. 82: 15-23. PMID: 1438665
- Circulating tuberculostearic acid in tuberculosis patients. | Traunmüller, F., et al. 2003. Scand J Infect Dis. 35: 790-3. PMID: 14723350
- A new short synthesis of 10R-tuberculostearic acid and its enantiomer. | Roberts, IO. and Baird, MS. 2006. Chem Phys Lipids. 142: 111-7. PMID: 16690044
- Rapid determination of growth inhibition of Mycobacterium tuberculosis by GC-MS/MS quantitation of tuberculostearic acid. | Cai, G., et al. 2013. Tuberculosis (Edinb). 93: 322-9. PMID: 23454100
- Measurement of tuberculostearic acid in sputa, pleural effusions, and bronchial washings. A clinical evaluation for diagnosis of pulmonary tuberculosis. | Muranishi, H., et al. 1990. Diagn Microbiol Infect Dis. 13: 235-40. PMID: 2383974
- Expression and characterization of Rv0447c product, potentially the methyltransferase involved in tuberculostearic acid biosynthesis in Mycobacterium tuberculosis. | Meena, LS. and Kolattukudy, PE. 2013. Biotechnol Appl Biochem. 60: 412-6. PMID: 24033595
- A tuberculostearic acid assay in the diagnosis of sputum smear-negative pulmonary tuberculosis. A prospective study of bronchoscopic aspirate and lavage specimens. | Pang, JA., et al. 1989. Ann Intern Med. 111: 650-4. PMID: 2802420
- Tuberculostearic acid, a potential parameter for scoring system construction for tuberculous meningitis diagnosis. | Fong, TH., et al. 2021. Int J Mycobacteriol. 10: 428-432. PMID: 34916463
- Tuberculostearic Acid-Containing Phosphatidylinositols as Markers of Bacterial Burden in Tuberculosis. | Brandenburg, J., et al. 2022. ACS Infect Dis. 8: 1303-1315. PMID: 35763439
- Tuberculostearic Acid Controls Mycobacterial Membrane Compartmentalization. | Prithviraj, M., et al. 2023. mBio. 14: e0339622. PMID: 36976029
- Tuberculostearic acid as a diagnostic marker in tuberculous meningitis. | Mårdh, PA., et al. 1983. Lancet. 1: 367. PMID: 6130374
- Use of selected ion monitoring for detection of tuberculostearic and C32 mycocerosic acid in mycobacteria and in five-day-old cultures of sputum specimens from patients with pulmonary tuberculosis. | Larsson, L., et al. 1981. Acta Pathol Microbiol Scand B. 89: 245-51. PMID: 6797240
- Synthesis of (R,S)-10-methyloctadecanoic acid (tuberculostearic acid) and key chiral 2-methyl branched intermediates. | Wallace, PA., et al. 1994. Chem Phys Lipids. 71: 145-62. PMID: 8076401
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tuberculostearic Acid, 5 mg | sc-475927 | 5 mg | $369.00 |