Molecular structure of Tubercidin, CAS Number: 69-33-0
Tubercidin (CAS 69-33-0)
Alternate Names:
7-Deazaadenosine; 4-amino-7β-D-ribofuranosyl-7H-pyrrolo[2, 3-d]pyrimidine
Application:
Tubercidin is an inhibitor of multiple metabolic processes such as RNA processing, nucleic acid synthesis, & protein synthesis
CAS Number:
69-33-0
Purity:
≥95%
Molecular Weight:
266.25
Molecular Formula:
C11H14N4O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tubercidin is a toxic adenosine analog with antiviral, antitrypanosomal, and antifungal functions. It inhibits multiple metabolic processes, including RNA processing, nucleic acid synthesis, protein synthesis, and methylation of tRNA through intracellular incorporation into nucleic acids. It acts as a plant antifungal, inhibits mammalian SAHH (SAH hydrolase), and blocks purine biosynthesis in Candida famata.
Tubercidin (CAS 69-33-0) References
- Three biotechnical processes using Ashbya gossypii, Candida famata, or Bacillus subtilis compete with chemical riboflavin production. | Stahmann, KP., et al. 2000. Appl Microbiol Biotechnol. 53: 509-16. PMID: 10855708
- The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNA interference library. | Drew, ME., et al. 2003. J Biol Chem. 278: 46596-600. PMID: 12972414
- BIOLOGICAL AND BIOCHEMICAL PROPERTIES OF THE ANALOGUE ANTIBIOTIC TUBERCIDIN. | ACS, G., et al. 1964. Proc Natl Acad Sci U S A. 52: 493-501. PMID: 14206615
- Efficacy of the tubercidin antileishmania action associated with an inhibitor of the nucleoside transport. | Aoki, JI., et al. 2009. Parasitol Res. 104: 223-8. PMID: 18787843
- Prevention of tubercidin host toxicity by nitrobenzylthioinosine 5'-monophosphate for the treatment of schistosomiasis. | el Kouni, MH., et al. 1989. Antimicrob Agents Chemother. 33: 824-7. PMID: 2764531
- Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090. | Liu, Y., et al. 2018. Microb Cell Fact. 17: 131. PMID: 30153835
- Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity. | Hulpia, F., et al. 2019. Eur J Med Chem. 164: 689-705. PMID: 30677668
- The Trypanosoma cruzi TcrNT2 Nucleoside Transporter Is a Conduit for the Uptake of 5-F-2'-Deoxyuridine and Tubercidin Analogues. | Aldfer, MM., et al. 2022. Molecules. 27: PMID: 36432150
- Action of tubercidin and other adenosine analogs on Schistosoma mansoni schistosomules. | Dovey, HF., et al. 1985. Mol Biochem Parasitol. 16: 185-98. PMID: 3929087
- Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphate. | el Kouni, MH., et al. 1983. Proc Natl Acad Sci U S A. 80: 6667-70. PMID: 6579551
- Antiviral activity of C-5 substituted tubercidin analogues. | Bergstrom, DE., et al. 1984. J Med Chem. 27: 285-92. PMID: 6699874
- Tubercidin stabilizes microtubules against vinblastine-induced depolymerization, a taxol-like effect. | Mooberry, SL., et al. 1995. Cancer Lett. 96: 261-6. PMID: 7585466
- Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver. | Fabianowska-Majewska, K., et al. 1994. Biochem Pharmacol. 48: 897-903. PMID: 8093102
Inhibitor of:
Adenosine deaminase, AK8, ANT1, CNT1, DERA, DHX33, Nop10, NXT-1, PKR, Ribosomal Protein LP0, Rpp30, SAHH, SLC29 (solute carrier family 29), and UCK1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tubercidin, 10 mg | sc-258322 | 10 mg | $184.00 | |||
Tubercidin, 50 mg | sc-258322A | 50 mg | $663.00 | |||
Tubercidin, 250 mg | sc-258322B | 250 mg | $1958.00 |