Tuba Antibody (MH-8): sc-135592

Tuba Antibody (MH-8) is a mouse monoclonal IgG3 kappa light chain antibody that detects Tuba protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Tuba antibody (MH-8) is available as the non-conjugated form. Tuba, also known as Dynamin binding protein (DNMBP), is a crucial 1,577 amino acid protein that plays a significant role in cellular organization and function. Tuba protein is primarily located in the cytoplasm, cytoskeleton, cell junctions, and Golgi apparatus, where Tuba (MH-8) serves as a scaffold protein that links Dynamin with actin-regulating proteins, thereby facilitating protein trafficking between the Golgi and cell surface. This trafficking is vital for maintaining cellular homeostasis and ensuring proteins reach correct destinations, which is essential for various cellular processes, including secretion and membrane dynamics. Tuba protein is expressed in multiple tissues, including kidney, heart, lung, liver, brain, pancreas, and skeletal muscle, highlighting Tuba′s importance in diverse physiological functions. Additionally, two isoforms of Tuba exist due to alternative splicing events, which may contribute to functional versatility. The gene encoding Tuba is located on human chromosome 10, a region that contains over 1,200 genes and is implicated in several genetic disorders, including Charcot-Marie-Tooth disease and multiple endocrine neoplasia type 2.

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Tuba Antibody (MH-8) References:

1. Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.  |  Nagase, T., et al. 1999. DNA Res. 6: 63-70. PMID: 10231032
2. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton.  |  Salazar, MA., et al. 2003. J Biol Chem. 278: 49031-43. PMID: 14506234
3. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.  |  Kuwano, R., et al. 2006. Hum Mol Genet. 15: 2170-82. PMID: 16740596
4. Cdc42 GEF Tuba regulates the junctional configuration of simple epithelial cells.  |  Otani, T., et al. 2006. J Cell Biol. 175: 135-46. PMID: 17015620
5. No association of dynamin binding protein (DNMBP) gene SNPs and Alzheimer's disease.  |  Minster, RL., et al. 2008. Neurobiol Aging. 29: 1602-4. PMID: 17442457
6. DNMBP is genetically associated with Alzheimer dementia in the Belgian population.  |  Bettens, K., et al. 2009. Neurobiol Aging. 30: 2000-9. PMID: 18359537
7. Association analysis of dynamin-binding protein (DNMBP) on chromosome 10q with late onset Alzheimer's disease in a large caucasian UK sample.  |  Morgan, AR., et al. 2009. Am J Med Genet B Neuropsychiatr Genet. 150B: 61-4. PMID: 18452187