TSLPR Antibody (4A11): sc-293312
- TSLPR Antibody (4A11) is a mouse monoclonal IgG2a κ TSLPR antibody, cited in 1 publications, provided at 100 µg/ml
- raised against amino acids 23-132 of TSLPR of human origin
- recommended for detection of TSLPR of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TSLPR Antibody (4A11). This work is in progress.
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TSLPR Antibody (4A11) is a mouse monoclonal IgG2a kappa light chain antibody that detects the TSLPR protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TSLPR antibody (4A11) is available as the non-conjugated format. Thymic stromal lymphopoietin (TSLP) plays a crucial role in the immune system by promoting the development and differentiation of B cells, which are essential for adaptive immunity. TSLP protein is primarily located in the thymus and other lymphoid tissues, where epithelial cells secrete TSLP to act on various immune cells. This localization is significant because TSLP can influence the development of immune responses at the site where T cells mature, thereby shaping the overall immune landscape. TSLP exerts effects by binding to TSLPR receptor, forming a complex with IL-7 receptor alpha (IL-7Ra), which is critical for signaling pathways that lead to cell survival and proliferation. The interaction between TSLP and TSLPR is vital for maintaining immune homeostasis and preventing excessive inflammation, highlighting TSLPR′s importance in immune regulation.
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TSLPR Antibody (4A11) References:
- Requirement for stat5 in thymic stromal lymphopoietin-mediated signal transduction. | Isaksen, DE., et al. 1999. J Immunol. 163: 5971-7. PMID: 10570284
- Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. | Pandey, A., et al. 2000. Nat Immunol. 1: 59-64. PMID: 10881176
- Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. | Park, LS., et al. 2000. J Exp Med. 192: 659-70. PMID: 10974032
- Molecular cloning and biological characterization of a novel murine lymphoid growth factor. | Sims, JE., et al. 2000. J Exp Med. 192: 671-80. PMID: 10974033
- Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. | Reche, PA., et al. 2001. J Immunol. 167: 336-43. PMID: 11418668
- Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. | Quentmeier, H., et al. 2001. Leukemia. 15: 1286-92. PMID: 11480573
- Function and mechanisms of TSLP/TSLPR complex in asthma and COPD. | Redhu, NS. and Gounni, AS. 2012. Clin Exp Allergy. 42: 994-1005. PMID: 22168549
- Anti-TSLP antibodies: Targeting a master regulator of type 2 immune responses. | Nakajima, S., et al. 2020. Allergol Int. 69: 197-203. PMID: 31974038
- Epithelial cell alarmin cytokines: Frontline mediators of the asthma inflammatory response. | Duchesne, M., et al. 2022. Front Immunol. 13: 975914. PMID: 36311787
- TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts. | Wang, D., et al. 2023. Int Immunopharmacol. 121: 110430. PMID: 37364323
- Preclinical development of 1B7/CD3, a novel anti-TSLPR bispecific antibody that targets CRLF2-rearranged Ph-like B-ALL. | Tian, Z., et al. 2023. Leukemia. 37: 2006-2016. PMID: 37634013
- Thymic stromal lymphopoietin: a cytokine that promotes the development of IgM+ B cells in vitro and signals via a novel mechanism. | Levin, SD., et al. 1999. J Immunol. 162: 677-83. PMID: 9916685
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSLPR Antibody (4A11) | sc-293312 | 100 µg/ml | $322.00 |