TRP1 Antibody (4D25): sc-73239
- TRP1 Antibody (4D25) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against melenoma cell line SK-MEL-23 of human origin
- recommended for detection of TRP1 in melanomas of mouse, rat and human origin by WB and IF; non cross-reactive with carcinomas and sarcomas
- See TRP1 (G-9): sc-166857 for TRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TRP1 Antibody (4D25) for WB applications. These reagents are now offered in bundles with TRP1 Antibody (4D25) (see ordering information below).
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TRP1 Antibody (4D25) is a mouse monoclonal IgG2a light chain antibody that detects TRP1 in mouse, rat, and human samples through western blotting (WB) and immunofluorescence (IF) applications. TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, specifically in the production of eumelanin, which is essential for pigmentation in skin, hair, and eyes. TRP1 is primarily located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the conversion of tyrosine to melanin. Proper localization of TRP1 within the melanosomal membrane is vital, as such positioning ensures efficient interaction with partner proteins and optimal enzymatic activity. Disruptions in TRP1 function or expression can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal pigmentation and protecting against UV radiation. Anti-TRP1 antibody (4D25) is an invaluable tool for researchers studying melanin synthesis, pigmentation disorders, and the molecular mechanisms underlying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRP1 Antibody (4D25) References:
- Functional significance of human trp1 and trp3 in store-operated Ca(2+) entry in HEK-293 cells. | Wu, X., et al. 2000. Am J Physiol Cell Physiol. 278: C526-36. PMID: 10712241
- Inhibition of endogenous TRP1 decreases capacitative Ca2+ entry and attenuates pulmonary artery smooth muscle cell proliferation. | Sweeney, M., et al. 2002. Am J Physiol Lung Cell Mol Physiol. 283: L144-55. PMID: 12060571
- The Metarhizium anisopliae trp1 gene: cloning and regulatory analysis. | Staats, CC., et al. 2004. Curr Microbiol. 49: 66-70. PMID: 15297933
- Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. | Thanos, A., et al. 2012. Am J Pathol. 180: 1917-27. PMID: 22429967
- Cloning and analysis of the Kluyveromyces lactis TRP1 gene: a chromosomal locus flanked by genes encoding inorganic pyrophosphatase and histone H3. | Stark, MJ. and Milner, JS. 1989. Yeast. 5: 35-50. PMID: 2538971
- Targeting steroid receptor RNA activator (SRA), a long non-coding RNA, enhances melanogenesis through activation of TRP1 and inhibition of p38 phosphorylation. | Ho, JC., et al. 2020. PLoS One. 15: e0237577. PMID: 32790741
- The role of the TRP1 gene in yeast tryptophan biosynthesis. | Braus, GH., et al. 1988. J Biol Chem. 263: 7868-75. PMID: 3286643
- Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. | Tschumper, G. and Carbon, J. 1980. Gene. 10: 157-66. PMID: 6248420
- Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. | Kobayashi, T., et al. 1994. EMBO J. 13: 5818-25. PMID: 7813420
- Suppressors of trp1 fluorescence identify a new arabidopsis gene, TRP4, encoding the anthranilate synthase beta subunit. | Niyogi, KK., et al. 1993. Plant Cell. 5: 1011-27. PMID: 8400875
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRP1 Antibody (4D25) | sc-73239 | 200 µg/ml | $322.00 | |||
TRP1 Antibody (4D25): m-IgG Fc BP-HRP Bundle | sc-539463 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRP1 Antibody (4D25): m-IgG2a BP-HRP Bundle | sc-546708 | 200 µg Ab; 10 µg BP | $361.00 |