TRP1 Antibody (4D25): sc-73239
- TRP1 Antibody (4D25) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against melenoma cell line SK-MEL-23 of human origin
- recommended for detection of TRP1 in melanomas of mouse, rat and human origin by WB and IF; non cross-reactive with carcinomas and sarcomas
- See TRP1 (G-9): sc-166857 for TRP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for TRP1 Antibody (4D25) for WB applications. These reagents are now offered in bundles with TRP1 Antibody (4D25) (see ordering information below).
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TRP1 Antibody (4D25) is a mouse monoclonal IgG2a light chain antibody that detects TRP1 in mouse, rat, and human samples through western blotting (WB) and immunofluorescence (IF) applications. TRP1, or tyrosinase-related protein 1, plays a crucial role in the melanin biosynthesis pathway, specifically in the production of eumelanin, which is essential for pigmentation in skin, hair, and eyes. TRP1 is primarily located in the melanosomes of melanocytes, where TRP1 works in concert with other enzymes, including tyrosinase and TRP2, to facilitate the conversion of tyrosine to melanin. Proper localization of TRP1 within the melanosomal membrane is vital, as such positioning ensures efficient interaction with partner proteins and optimal enzymatic activity. Disruptions in TRP1 function or expression can lead to pigmentation disorders, highlighting TRP1′s importance in maintaining normal pigmentation and protecting against UV radiation. Anti-TRP1 antibody (4D25) is an invaluable tool for researchers studying melanin synthesis, pigmentation disorders, and the molecular mechanisms underlying these processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRP1 Antibody (4D25) | sc-73239 | 200 µg/ml | $316.00 | |||
TRP1 Antibody (4D25): m-IgG Fc BP-HRP Bundle | sc-539463 | 200 µg Ab; 10 µg BP | $354.00 | |||
TRP1 Antibody (4D25): m-IgG2a BP-HRP Bundle | sc-546708 | 200 µg Ab; 10 µg BP | $354.00 |