Troponin I-C Antibody (G-11): sc-376662
- Troponin I-C Antibody (G-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 55-95 mapping near the N-terminus of Troponin I-C of human origin
- Troponin I-C Antibody (G-11) is recommended for detection of Troponin I-C of human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
- Anti-Troponin I-C Antibody (G-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Troponin I-C Antibody (G-11). This work is in progress.
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Troponin I-C Antibody (G-11) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect Troponin I-C, also known as cardiac troponin I (cTnI), slow skeletal troponin I, and fast skeletal troponin I, across multiple species including human, canine, and bovine. Anti-Troponin I-C antibody (G-11) targets an epitope mapping to amino acids 55-95 near the N-terminus of human Troponin I-C, ensuring precise and reliable binding for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Troponin I-C is a critical component of the troponin complex located within the sarcomere of striated muscle cells, where Troponin I-C plays an essential role in regulating muscle contraction by inhibiting the interaction between actin and myosin in the absence of calcium ions. The strategic location of Troponin I-C in the thin filament is vital for the fine-tuned control of cardiac and skeletal muscle contraction, making Troponin I-C a key biomarker for cardiac injury and muscle physiology studies. Troponin I-C monoclonal antibody (G-11) facilitates the investigation of interactions with other troponin subunits such as Troponin T (cTnT) and Troponin C (cTnC), as well as with regulatory proteins like tropomyosin, which are crucial for maintaining muscle function and responding to physiological stimuli. Additionally, anti-Troponin I-C antibody (G-11) recognizes Troponin I-C across multiple species, enhancing utility in comparative and translational research, providing valuable insights into muscle contraction mechanisms and related pathological conditions. Troponin I-C (G-11) antibody is an indispensable tool for researchers focused on cardiac biomarkers, muscle contraction dynamics, and cardiovascular diseases, offering high specificity and sensitivity for accurate detection and analysis of Troponin I-C within cellular and tissue contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Troponin I-C Antibody (G-11) References:
- Structure and expression of the murine slow/cardiac troponin C gene. | Parmacek, MS. and Leiden, JM. 1989. J Biol Chem. 264: 13217-25. PMID: 2753913
- cDNA clone and expression analysis of rodent fast and slow skeletal muscle troponin I mRNAs. | Koppe, RI., et al. 1989. J Biol Chem. 264: 14327-33. PMID: 2760067
- A direct regulatory role for troponin T and a dual role for troponin C in the Ca2+ regulation of muscle contraction. | Potter, JD., et al. 1995. J Biol Chem. 270: 2557-62. PMID: 7852318
- Structure and regulation of the mouse cardiac troponin I gene. | Ausoni, S., et al. 1994. J Biol Chem. 269: 339-46. PMID: 8276817
- Actin cytoskeleton. Setting the pace of cell movement. | Barkalow, K. and Hartwig, JH. 1995. Curr Biol. 5: 1000-2. PMID: 8542272
- Myosins: matching functions with motors. | Baker, JP. and Titus, MA. 1998. Curr Opin Cell Biol. 10: 80-6. PMID: 9484598
- A new look at thin filament regulation in vertebrate skeletal muscle. | Squire, JM. and Morris, EP. 1998. FASEB J. 12: 761-71. PMID: 9657517
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Troponin I-C Antibody (G-11) | sc-376662 | 200 µg/ml | $322.00 | |||
Troponin I-C Antibody (G-11) AC | sc-376662 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Troponin I-C Antibody (G-11) HRP | sc-376662 HRP | 200 µg/ml | $322.00 | |||
Troponin I-C Antibody (G-11) FITC | sc-376662 FITC | 200 µg/ml | $336.00 | |||
Troponin I-C Antibody (G-11) PE | sc-376662 PE | 200 µg/ml | $349.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 488 | sc-376662 AF488 | 200 µg/ml | $364.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 546 | sc-376662 AF546 | 200 µg/ml | $364.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 594 | sc-376662 AF594 | 200 µg/ml | $364.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 647 | sc-376662 AF647 | 200 µg/ml | $364.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 680 | sc-376662 AF680 | 200 µg/ml | $364.00 | |||
Troponin I-C Antibody (G-11) Alexa Fluor® 790 | sc-376662 AF790 | 200 µg/ml | $364.00 |