Tropomyosin Antibody (CH1): sc-58868
- Tropomyosin Antibody (CH1) is a mouse monoclonal IgG1 κ, cited in 9 publications, provided at 200 µg/ml
- raised against purified muscle Tropomyosin of chicken origin
- recommended for detection of striated muscle forms of Tropomyosin, including cardiac α Tropomyosin and skeletal muscle forms of Tropomyosin of mouse, rat, human, avian and Xenopus origin by WB, IP, IF and IHC(P); may cross-react with chicken cardiac muscle; non cross-reactive with smooth muscle or non-muscle isoforms of Tropomyosin
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Tropomyosin Antibody (CH1) for WB and IHC(P) applications. These reagents are now offered in bundles with Tropomyosin Antibody (CH1) (see ordering information below).
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Tropomyosin Antibody (CH1) is a mouse monoclonal IgG1 antibody that detects Tropomyosin in mouse, rat, human, and avian species through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Tropomyosin plays a crucial role in muscle contraction and cellular structure by binding to actin filaments, thereby stabilizing their structure and regulating the interaction between actin and myosin. This interaction is vital for muscle function, as it allows for the precise control of muscle contraction and relaxation. Tropomyosin is encoded by two genes, TPM1 and TPM2, which undergo alternative splicing to produce various isoforms that are specific to different muscle types and non-muscle tissues. The presence of these isoforms allows for specialized functions in diverse cellular contexts, highlighting the importance of Tropomyosin in both muscle and non-muscle cells. Additionally, Tropomyosin interacts with other proteins such as Troponin I and Caldesmon, which further modulate its role in muscle contraction and cellular signaling pathways. Anti-Tropomyosin antibody (CH1) is an essential tool for researchers studying muscle biology, cytoskeletal dynamics, and the molecular mechanisms underlying muscle-related diseases.
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Tropomyosin Antibody (CH1) References:
- Role of tropomyosin in the regulation of contraction in smooth muscle. | Marston, S. and El-Mezgueldi, M. 2008. Adv Exp Med Biol. 644: 110-23. PMID: 19209817
- Polymorphism in tropomyosin structure and function. | Janco, M., et al. 2013. J Muscle Res Cell Motil. 34: 177-87. PMID: 23832280
- A systematic nomenclature for mammalian tropomyosin isoforms. | Geeves, MA., et al. 2015. J Muscle Res Cell Motil. 36: 147-53. PMID: 25369766
- Tropomyosin-Mediated Regulation of Cytoplasmic Myosins. | Manstein, DJ. and Mulvihill, DP. 2016. Traffic. 17: 872-7. PMID: 27060364
- Tropomyosin pseudo-phosphorylation results in dilated cardiomyopathy. | Rajan, S., et al. 2019. J Biol Chem. 294: 2913-2923. PMID: 30567734
- Neurotrophic tropomyosin or t yrosine receptor kinase (NTRK) genes. | Chetty, R. 2019. J Clin Pathol. 72: 187-190. PMID: 30636697
- Targeting tropomyosin receptor kinase for cancer therapy. | Miao, Q., et al. 2019. Eur J Med Chem. 175: 129-148. PMID: 31077998
- Tropomyosin-Related Kinase Fusions in Gastrointestinal Stromal Tumors. | Lee, JH., et al. 2022. Cancers (Basel). 14: PMID: 35681640
- Ultrasensitive Quantification of Crustacean Tropomyosin by Immuno-PCR. | Radomirović, M., et al. 2023. Int J Mol Sci. 24: PMID: 37895089
- Tropomyosin-troponin complex in inherited cardiomyopathies. | Juárez, CK., et al. 2024. Heart Rhythm. 21: 1173-1175. PMID: 38382684
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tropomyosin Antibody (CH1) | sc-58868 | 200 µg/ml | $322.00 | |||
Tropomyosin Antibody (CH1): m-IgG Fc BP-HRP Bundle | sc-539104 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tropomyosin Antibody (CH1): m-IgG1 BP-HRP Bundle | sc-541262 | 200 µg Ab; 20 µg BP | $361.00 |