Molecular structure of Tropisetron hydrochloride, CAS Number: 105826-92-4
Tropisetron hydrochloride (CAS 105826-92-4)
See product citations (2)
Alternate Names:
(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 1H-indole-3-carboxylic acid ester monohydrochloride
Application:
Tropisetron hydrochloride is a potent SR-3 antagonist
CAS Number:
105826-92-4
Purity:
≥99%
Molecular Weight:
320.82
Molecular Formula:
C17H20N2O2•HCl
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Tropisetron hydrochloride is a potent SR (SR-3) antagonist. It is also a selective, partial agonist at AChR alpha 7 (alpha7 nicotinic receptors). Tropisetron hydrochloride is an inhibitor of HTR3.
Tropisetron hydrochloride (CAS 105826-92-4) References
- Low-dose dexamethasone reduces nausea and vomiting after tympanomastoid surgery: a comparison of tropisetron with saline. | Wang, JJ., et al. 2002. Am J Otolaryngol. 23: 267-71. PMID: 12239690
- Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study. | Yu, L., et al. 2007. J Chromatogr B Analyt Technol Biomed Life Sci. 846: 20-3. PMID: 16962390
- [Tropisetron hydrochloride in preventing and treating chemotherapy-induced nausea and vomiting: a phase II, randomized, multicenter, double-blinded, comparative clinical trial]. | Zhang, WD., et al. 2007. Ai Zheng. 26: 870-3. PMID: 17697550
- [Prophylactic effect of tropisetron hydrochloride against nausea and vomiting in patients receiving chemotherapy for hematological malignancies]. | Nomura, K., et al. 2007. Gan To Kagaku Ryoho. 34: 1513-5. PMID: 17876159
- Experimental examination of anti-inflammatory effects of a 5-HT3 receptor antagonist, tropisetron, and concomitant effects on autonomic nervous function in a rat sepsis model. | Setoguchi, D., et al. 2011. Int Immunopharmacol. 11: 2073-8. PMID: 21924384
- Study on the interactions of antiemetic drugs and 12-tungstophosphoric acid by absorption and resonance Rayleigh scattering spectra and their analytical applications. | Wang, Y., et al. 2013. Spectrochim Acta A Mol Biomol Spectrosc. 105: 612-7. PMID: 23391849
- Stability of butorphanol-tropisetron mixtures in 0.9% sodium chloride injection for patient-controlled analgesia use. | Chen, FC., et al. 2015. Medicine (Baltimore). 94: e432. PMID: 25674732
- Stability of tramadol with three 5-HT3 receptor antagonists in polyolefin bags for patient-controlled delivery systems. | Chen, FC., et al. 2016. Drug Des Devel Ther. 10: 1869-75. PMID: 27350741
- Compatibility of dexamethasone sodium phosphate with 5-HT3 receptor antagonists in infusion solutions: a comprehensive study. | He, G., et al. 2017. Eur J Hosp Pharm. 24: 162-166. PMID: 31156929
- [Effect of acupuncture in different time on nausea and vomiting induced by chemotherapy of lung cancer]. | Wang, YL., et al. 2019. Zhongguo Zhen Jiu. 39: 1269-73. PMID: 31820600
- Compatible stability of methylprednisolone sodium succinate and tropisetron in 0.9% sodium chloride injection. | Peng, C. and Lei, JX. 2020. Eur J Hosp Pharm. 27: e58-e62. PMID: 32296507
- To Explore the Effects of Acupuncture and Medical Treatment at Different Times on the Gastrointestinal Reaction and White Blood Cell Count of Patients with Lung Cancer Chemotherapy. | Zhao, Q., et al. 2022. Appl Bionics Biomech. 2022: 5261344. PMID: 35432592
Inhibitor of:
GPR171, HTR3, HTR3C, HTR3E, Olfr952, SPBP, and SR.Activator of:
AChR α 7, HCNP, and SR-3B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tropisetron hydrochloride, 10 mg | sc-204930 | 10 mg | $96.00 | |||
Tropisetron hydrochloride, 50 mg | sc-204930A | 50 mg | $571.00 |