Trophinin Antibody (clone 3-11): sc-80002

Trophinin Antibody (clone 3-11) is a mouse monoclonal IgM antibody that detects Trophinin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Trophinin (clone 3-11) antibody is available as the non-conjugated form. Trophinin, also known as TRO or MAGED3, is a crucial apical cell adhesion molecule that plays a significant role in embryo implantation by interacting with and forming a complex with Bystin and Tastin, thereby facilitating cell adhesion. Trophinin is predominantly located in the membrane of chorionic villi trophoblasts and maternal endometrial epithelial cells, with expression being dependent on implantation. Trophinin mediates cell adhesion between trophoblastic and endometrial epithelial cells through homophilic Trophinin-Trophinin binding, which is essential for successful implantation. Notably, Trophinin expression is induced by Choriogonadotropin β and interleukin-1 beta, and higher levels of Trophinin correlate with increased cell adhesion rates. Enhancing Trophinin expression could be a strategic approach to improve implantation rates, making Trophinin a protein of interest in reproductive biology. Additionally, Trophinin is found in macrophages and contains one MAGE (melanoma-associated antigen) domain, further highlighting diverse biological roles.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Trophinin Antibody (clone 3-11) References:

1. Cancer/testis antigens: structural and immunobiological properties.  |  Kirkin, AF., et al. 2002. Cancer Invest. 20: 222-36. PMID: 11901543
2. Expression of trophinin in the cycling endometrium and its association with infertility.  |  Wang, HY., et al. 2002. Di Yi Jun Yi Da Xue Xue Bao. 22: 539-41. PMID: 12297480
3. Trophinin is expressed in the porcine endometrium during the estrous cycle.  |  Nakano, S., et al. 2003. J Reprod Dev. 49: 127-34. PMID: 14967937
4. Comparative expression analysis of the MAGED genes during embryogenesis and brain development.  |  Bertrand, M., et al. 2004. Dev Dyn. 230: 325-34. PMID: 15162511
5. Apical cell adhesion molecule, trophinin, localizes to the nuclear envelope.  |  Aoyama, J., et al. 2005. FEBS Lett. 579: 6326-32. PMID: 16288751
6. Expression of trophinin and bystin identifies distinct cell types in the germinal zones of adult rat brain.  |  Ma, L., et al. 2006. Eur J Neurosci. 23: 2265-76. PMID: 16706835
7. Signal transduction in human embryo implantation.  |  Fukuda, MN. and Sugihara, K. 2007. Cell Cycle. 6: 1153-6. PMID: 17495530
8. Induction of trophinin in human endometrial surface epithelia by CGbeta and IL-1beta.  |  Sugihara, K., et al. 2008. FEBS Lett. 582: 197-202. PMID: 18078818

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Trophinin Antibody (clone 3-11) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Trophinin Antibody (clone 3-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Trophinin Antibody (clone 3-11) Specifications

Alternate Product Name: Trophinin

Product Clone Name: clone 3-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 681-689

Epitope Target: Trophinin

Epitope Species: human

Product Reactivity/Detection: Trophinin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Trophinin Antibody (clone 3-11): N/A