Date published: 2026-4-24

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Tris(tert-butoxy)silanol (CAS 18166-43-3)

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Alternate Names:
TBS
CAS Number:
18166-43-3
Molecular Weight:
264.43
Molecular Formula:
C12H28O4Si
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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TBOS, or Tris(tert-butoxy)silanol finds extensive utility as a catalyst in organic synthesis due to its remarkable ability to activate diverse substrates. In the realm of biochemistry and molecular biology, it serves as a valuable reagent for the modification of proteins and other biomolecules. This organosilicon compound exhibits a distinctive capability to activate various substrates, including amines and alcohols, by forming covalent bonds with them. This covalent bonding, in turn, enables the synthesis of novel compounds. Moreover, Tris(tert-butoxy)silanol proves to be a versatile tool for the modification of proteins and other biomolecules. Its capacity to form covalent bonds with amino acids and other functional groups allows for precise and controlled alterations. This property facilitates the manipulation and customization of biomolecules to suit specific research or application requirements.


Tris(tert-butoxy)silanol (CAS 18166-43-3) References

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  2. Stepwise synthesis of siloxane chains.  |  Chang, Z., et al. 2004. Chem Commun (Camb). 206-7. PMID: 14737551
  3. Stable, microfabricated thin layer chromatography plates without volume distortion on patterned, carbon and Al₂O₃-primed carbon nanotube forests.  |  Jensen, DS., et al. 2012. J Chromatogr A. 1257: 195-203. PMID: 22926056
  4. Rapid atomic layer deposition of silica nanolaminates: synergistic catalysis of Lewis/Brønsted acid sites and interfacial interactions.  |  Fang, G. and Ma, J. 2013. Nanoscale. 5: 11856-69. PMID: 24126605
  5. The Detection and Reactivity of Silanols and Silanes Using Hyperpolarized 29 Si Nuclear Magnetic Resonance.  |  Rayner, PJ., et al. 2020. Angew Chem Int Ed Engl. 59: 2710-2714. PMID: 31833623
  6. Titanium(IV) Surface Complexes Bearing Chelating Catecholato Ligands for Enhanced Band-Gap Reduction.  |  Sonström, A., et al. 2023. Inorg Chem. 62: 715-729. PMID: 36595489

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tris(tert-butoxy)silanol, 25 g

sc-229647
25 g
$313.00