Tris(dimethylamino)phosphine (CAS 1608-26-0)

Tris(dimethylamino)phosphine is a versatile organophosphorus compound extensively utilized in various scientific applications. It exists as a colorless liquid and is commercially available in two forms: anhydrous and hydrated. In the realm of organic synthesis, it holds significant importance as a catalyst for producing a diverse range of organic molecules. Its applications extend to analytical chemistry, where it serves as a reagent to detect and quantify compounds like amino acids, peptides, and proteins. Additionally, in the field of biochemistry, it finds utility in measuring the activity of enzymes, such as proteases and phosphatases. The precise mechanism of action for Tris(dimethylamino)phosphine remains incompletely understood. However, it is believed to involve the formation of a phosphonium ion intermediate upon reacting with a substrate molecule. Subsequently, this intermediate can be targeted by nucleophiles, such as water molecules, resulting in the formation of product molecules.