Molecular structure of Tris(2-chloropropyl) Phosphate, CAS Number: 6145-73-9
Tris(2-chloropropyl) Phosphate (CAS 6145-73-9)
Alternate Names:
tris(b-Chloropropyl)phosphate
Application:
Tris(2-chloropropyl) Phosphate is A flame retardant chlorinated phosphate ester.
CAS Number:
6145-73-9
Molecular Weight:
327.57
Molecular Formula:
C9H18Cl3O4P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tris(2-chloropropyl) Phosphate is a chlorinated phosphate ester flame retardant used in rigid and flexible polyurethane foams. It is recommended as flame retardant for PU foams, PVC and adhesives. Tris(2-chloropropyl) phosphate, a well-known neurotoxin, has been associated with various detrimental health effects, such as reproductive and developmental toxicity, endocrine disruption, and cancer. Surprisingly, despite its toxic nature, Tris(2-chloropropyl) phosphate continues to be extensively utilized in consumer goods, including furniture, electronics, and various other products. The mechanism of action involves the inhibition of acetylcholinesterase, an enzyme responsible for breaking down the neurotransmitter acetylcholine. As a consequence, the accumulation of acetylcholine in the synapse occurs, leading to excessive stimulation of the nervous system.
Tris(2-chloropropyl) Phosphate (CAS 6145-73-9) References
- Degradation of organophosphoric esters in leachate from a sea-based solid waste disposal site. | Kawagoshi, Y., et al. 2002. Chemosphere. 48: 219-25. PMID: 12117057
- Selective determination of organophosphate flame retardants and plasticizers in indoor air by gas chromatography, positive-ion chemical ionization and collision-induced dissociation mass spectrometry. | Björklund, J., et al. 2004. Rapid Commun Mass Spectrom. 18: 3079-83. PMID: 15543547
- Investigation of cytotoxic, genotoxic, mutagenic, and estrogenic effects of the flame retardants tris-(2-chloroethyl)-phosphate (TCEP) and tris-(2-chloropropyl)-phosphate (TCPP) in vitro. | Föllmann, W. and Wober, J. 2006. Toxicol Lett. 161: 124-34. PMID: 16154716
- Quantification of two urinary metabolites of organophosphorus flame retardants by solid-phase extraction and gas chromatography-tandem mass spectrometry. | Schindler, BK., et al. 2009. Anal Bioanal Chem. 395: 1167-71. PMID: 19763550
- Non-target analysis of household dust and laundry dryer lint using comprehensive two-dimensional liquid chromatography coupled with time-of-flight mass spectrometry. | Ouyang, X., et al. 2017. Chemosphere. 166: 431-437. PMID: 27705830
- Leveling of Polymer Grating Structures upon Heating: Dimension Dependence on the Nanoscale and the Effect of Antiplasticizers. | Olaya-Muñoz, DA., et al. 2018. ACS Appl Mater Interfaces. 10: 27432-27443. PMID: 30033719
- Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans. | Xu, T., et al. 2017. Toxicol Res (Camb). 6: 63-72. PMID: 30090477
- OPFRs and BFRs induced A549 cell apoptosis by caspase-dependent mitochondrial pathway. | Yu, X., et al. 2019. Chemosphere. 221: 693-702. PMID: 30669111
- Assessment of input of organic micropollutants and microplastics into the Baltic Sea by urban waters. | Bollmann, UE., et al. 2019. Mar Pollut Bull. 148: 149-155. PMID: 31422298
- Assessment of gas-phase concentrations of organophosphate flame retardants at the material surface using a midget emission cell coupled to solid-phase microextraction. | Plaisance, H., et al. 2021. Anal Chim Acta. 1186: 339100. PMID: 34756255
- A high-throughput screening assay for identification of chemicals with liver tumor promoting potential using a transgenic zebrafish line. | Chen, S., et al. 2022. Chemosphere. 297: 134169. PMID: 35245594
- Plasma concentrations of tris(1-chloro-2-propyl) phosphate and a metabolite bis(2-chloroisopropyl) 1-carboxyethyl phosphate in Sprague-Dawley rats and B6C3F1/N mice from a chronic study of tris(chloropropyl) phosphate via feed. | Collins, B., et al. 2022. Toxicol Rep. 9: 690-698. PMID: 35433273
- Chlorinated organophosphorus flame retardants-induced mitochondrial abnormalities and the correlation with progesterone production in mLTC-1 cells. | Feng, Y., et al. 2022. Food Chem Toxicol. 169: 113432. PMID: 36115506
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tris(2-chloropropyl) Phosphate, 250 mg | sc-475151 | 250 mg | $312.00 | |||
Tris(2-chloropropyl) Phosphate, 1 g | sc-475151A | 1 g | $458.00 |