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Tris(2-chloroethyl) phosphite (CAS 140-08-9)

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CAS Number:
140-08-9
Molecular Weight:
269.49
Molecular Formula:
C6H12Cl3O3P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tris(2-chloroethyl) phosphite, known as TCEP, is an organophosphite compound that finds wide application in organic synthesis, biochemistry, and plastics as an additive. This colorless and odorless compound exhibits remarkable stability. Furthermore, Tris(2-chloroethyl) phosphite has found utility in nanoparticle synthesis, acting as a cross-linking agent for polymers. The precise mechanism of action of Tris(2-chloroethyl) phosphite remains partially understood. It is believed to function as a nucleophile in certain reactions while serving as a reducing agent in others. In polymerization reactions, it acts as a stabilizing agent, impeding the formation of undesired byproducts.


Tris(2-chloroethyl) phosphite (CAS 140-08-9) References

  1. The paper chromatography of esters of phosphoric and phosphorous acids.  |  MOULE, HA. and GREENFIELD, S. 1963. J Chromatogr. 11: 77-83. PMID: 13936301
  2. Traffic as a source of organophosphorus flame retardants and plasticizers in snow.  |  Marklund, A., et al. 2005. Environ Sci Technol. 39: 3555-62. PMID: 15952358
  3. Novel Organophosphate Esters in Airborne Particulate Matters: Occurrences, Precursors, and Selected Transformation Products.  |  Liu, X., et al. 2020. Environ Sci Technol. 54: 13771-13777. PMID: 33086790
  4. Flame retardation of polyurethanes by means of 1,4-bis[(dialkoxyphosphinyl)hydroxymethyl]benzene  |   and John A. Mikroyannidis. March 1988. Journal of Polymer Science Part A: Polymer Chemistry. Volume26, Issue3: Pages 885-900.
  5. Measuring Intra-Assay Agreement for the Ames Salmonella Assay  |  , et al. 1991. Statistical Methods in Toxicology. volume 43: pp 35–41.
  6. Trialkyl Phosphites and Diaryliodonium Salts as Co-initiators in a System for Radical-Promoted Visible-Light-Induced Cationic Polymerization (1)  |  Thomas W. Nalli*, Lee G. Stanek, Rebekka H. Molenaar, Krysia L. Weidell, Justin P. Meyer, Brandon R. Johnson, Timothy T. Steckler, Jay Wm. Wackerly, Missy Jo Studler, Kevin L. Vickerman, and Stephen A. Klankowski. 2013. J. Org. Chem., 78, 8,: 3561–3569.
  7. Why is tris(trimethylsilyl) phosphite effective as an additive for high-voltage lithium-ion batteries?†  |  Young-Kyu Han,*a Jaeik Yooa and Taeeun Yim*b. 2015,. J. Mater. Chem. A,. 3,: 10900-10909.
  8. Reaction of 2-cyano[(4-oxo-4H-chromen-3-yl)methylidene]acetohydrazide with phosphorus reagents: Synthesis and evaluation of anticancer activities of some novel 1,2-azaphospholes, 1,2,3-diazaphospholidine, and 1,3,2-diaza-phosphinanes bearing a chromone ring  |  Tarik E. Ali, et al. 2017 -. Synthetic Communications An International Journal for Rapid Communication of Synthetic Organic Chemistry. Volume 47, Issue 16: Pages 1458-1470.
  9. Visible-Light-Induced External Oxidant-Free Oxidative Phosphonylation of C(sp2)–H Bonds  |  Linbin Niu†, Jiamei Liu†, Hong Yi†, Shengchun Wang†, Xing-An Liang†, Atul K. Singh†, Chien-Wei Chiang†, and Aiwen Lei*†‡Orcid. 2017,. ACS Catal. 7, 11,: 7412–7416.
  10. A Simple and Convenient Strategy for the Synthesis of Novel Ten, Twelve, and Fourteen-membered Phosphorus Macrocyclic Compounds  |   and Mohan Challam Challa, Balakrishna Avula, Sravya Gundala, Mallikarjuna Reddy Guda, Grigory V. Zyryanov, Suresh Reddy Cirandur, Bakthavatchala Reddy Nemallapudi. March 2019. Journal of Heterocyclic Chemistry. Volume56, Issue3: Pages 818-823.
  11. Synthesis of Some Novel Thiadiazaphosphole, Oxazaphospholothiadiazaphosphole, Thiadiazaphosphinine, and Phosphonates Containing a 1,2,4-Triazine Moiety  |   and Somaia M. Abdel-kariem. July 2019. Journal of Heterocyclic Chemistry. Volume56, Issue7: Pages 1922-1927.
  12. Novel phospha-oxazepinoquinazolinyl derivatives of ibuprofen as nitric oxide synthase inhibitors: Synthesis and biological evaluation  |  AM Algohary, MM Hassan - Arabian Journal of Chemistry, 2022 - Elsevier. March 2022,. Arabian Journal of Chemistry. Volume 15, Issue 3,: 103642.
  13. Acid and 1, 2-Dichloroethane Co-Promoted Substitution of the Amino Groups in Gramine and its Analogues with Trialkyl Phosphites  |   and Dr. Shengmei Guo, Zhebin Zhang, Jianxin Xu, Sen Li, Prof. Zhengjiang Fu, Prof. Hu Cai. December 30, 2019. ChemistrySelect. Volume4, Issue48: Pages 14111-14113.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tris(2-chloroethyl) phosphite, 5 g

sc-251392
5 g
$194.00

Tris(2-chloroethyl) phosphite, 25 g

sc-251392A
25 g
$326.00

Tris(2-chloroethyl) phosphite, 100 g

sc-251392B
100 g
$561.00